About: Effect of dimethyl sulfoxide in cerebellar mutant Lurcher mice

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://ac.els-cdn.com/S0304394013002759/1-s2.0-S0304394013002759-main.pdf?_tid=63c90cda-097b-11e3-a29c-00000aab0f01&acdnat=1376991311_bdf9283d61c8680bc2d025dc056fbd25
Description	DMSO has been many times described as harmless substance, beneficial in various diseases or pathological states, including brain injury or ischemia. Using Lurcher mutant mice suffering from genetically determined olivocerebellar degeneration and normal wild type mice, we examined the effect of DMSO on spontaneous motor activity and spatial learning and orientation ability. The acute effect of DMSO was studied in mice aged 3, 6, 9 and 22 weeks. DMSO treatment decreased spontaneous activity in the open field and swimming speed in the Morris water maze in both Lurcher mutant and wild type mice. While saline-treated Lurcher mice showed age-related decline of spatial memory in the Morris water maze in DMSO-treated ones such decline did not occur. The mechanism of the effect of DMSO remains unclear. A possible explanation could be modulation of the brain perfusion and metabolism in the aging brain. The improvement of learning ability could be also mediated by a tranquilizing effect of DMSO reducing stress-induced behavioral disinhibition which is supposed to interfere with learning process in Lurcher mutants. Future studies which would investigate DMSO effects in other models of neurodegenerative diseases are necessary to verify its potential therapeutic impact. DMSO has been many times described as harmless substance, beneficial in various diseases or pathological states, including brain injury or ischemia. Using Lurcher mutant mice suffering from genetically determined olivocerebellar degeneration and normal wild type mice, we examined the effect of DMSO on spontaneous motor activity and spatial learning and orientation ability. The acute effect of DMSO was studied in mice aged 3, 6, 9 and 22 weeks. DMSO treatment decreased spontaneous activity in the open field and swimming speed in the Morris water maze in both Lurcher mutant and wild type mice. While saline-treated Lurcher mice showed age-related decline of spatial memory in the Morris water maze in DMSO-treated ones such decline did not occur. The mechanism of the effect of DMSO remains unclear. A possible explanation could be modulation of the brain perfusion and metabolism in the aging brain. The improvement of learning ability could be also mediated by a tranquilizing effect of DMSO reducing stress-induced behavioral disinhibition which is supposed to interfere with learning process in Lurcher mutants. Future studies which would investigate DMSO effects in other models of neurodegenerative diseases are necessary to verify its potential therapeutic impact. (en)
Title	Effect of dimethyl sulfoxide in cerebellar mutant Lurcher mice Effect of dimethyl sulfoxide in cerebellar mutant Lurcher mice (en)
skos:prefLabel	Effect of dimethyl sulfoxide in cerebellar mutant Lurcher mice Effect of dimethyl sulfoxide in cerebellar mutant Lurcher mice (en)
skos:notation	RIV/00216208:11140/13:10138961!RIV14-MSM-11140___
http://linked.open...avai/predkladatel	Lékařská fakulta v Plzni
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(ED2.1.00/03.0076)
http://linked.open...iv/cisloPeriodika	may
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Markvartová, Věra Vožeh, František Cendelín, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Lékařská fakulta v Plzni
http://linked.open...dnocenehoVysledku	71472
http://linked.open...ai/riv/idVysledku	RIV/00216208:11140/13:10138961
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Spatial orientation; Olivocerebellar degeneration; Lurcher mouse; Dimethyl sulfoxide (en)
http://linked.open.../riv/klicoveSlovo	Dimethyl sulfoxide Lurcher mouse Spatial orientation Olivocerebellar degeneration
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[B31862F29902]
http://linked.open...i/riv/nazevZdroje	Neuroscience Letters
http://linked.open...in/vavai/riv/obor	FH
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Biomedical Centre of the Faculty of Medicine in Pilsen
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	543
http://linked.open...iv/tvurceVysledku	Vožeh, František Cendelín, Jan Markvartová, Věra
http://linked.open...ain/vavai/riv/wos	000319646000028
issn	0304-3940
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.neulet.2013.03.034
http://localhost/t...ganizacniJednotka	11140

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