About: Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia     Goto   Sponge   NotDistinct   Permalink

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Description
  • Pediatric acute myeloid leukemia (AML) is a heterogeneous malignant disease, characterized by abnormal proliferation and impaired differentiation of myeloid cells. Acquired cytogenetic aberrations such as t(8;21)(q22;q22)/AML-ETO, inv(16)(p13q22)/CBFβ-MYH11, t(15;17)(q22;q21)/PML-RARα, rearrangements involving MLL and molecular aberrations in genes such as FLT3, NPM1, CEBPA and WT1 are involved in AML pathogenesis and are prognostic factors for treatment outcome.
  • Pediatric acute myeloid leukemia (AML) is a heterogeneous malignant disease, characterized by abnormal proliferation and impaired differentiation of myeloid cells. Acquired cytogenetic aberrations such as t(8;21)(q22;q22)/AML-ETO, inv(16)(p13q22)/CBFβ-MYH11, t(15;17)(q22;q21)/PML-RARα, rearrangements involving MLL and molecular aberrations in genes such as FLT3, NPM1, CEBPA and WT1 are involved in AML pathogenesis and are prognostic factors for treatment outcome. (en)
Title
  • Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia
  • Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia (en)
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  • Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia
  • Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia (en)
skos:notation
  • RIV/00216208:11130/13:10196739!RIV14-MSM-11130___
http://linked.open...avai/predkladatel
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  • 110230
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  • RIV/00216208:11130/13:10196739
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  • expression; aberrations; cells (en)
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  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [28447064E1A2]
http://linked.open...i/riv/nazevZdroje
  • Leukemia
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  • 27
http://linked.open...iv/tvurceVysledku
  • Baruchel, A.
  • Pieters, R.
  • Reinhardt, D.
  • Trka, Jan
  • Zimmermann, M.
  • Coenen, E. A.
  • de Haas, V.
  • Aalbers, A. M.
  • Zwaan, C. M.
  • van den Heuvel-Eibrink, M. M.
  • van der Velden, V. H. J.
  • Wu, C.
  • Calado, R. T.
  • Geleijns, K.
  • Kajigaya, S.
  • Kaspers, G. J. L.
  • Kuijpers, T. W.
  • Young, N. S.
http://linked.open...ain/vavai/riv/wos
  • 000322823200029
issn
  • 0887-6924
number of pages
http://bibframe.org/vocab/doi
  • 10.1038/leu.2013.57
http://localhost/t...ganizacniJednotka
  • 11130
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