About: An admixture analysis of the age at index episodes in bipolar disorder

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://dx.doi.org/10.1016/j.psychres.2010.10.033
Description	The interaction between polarity at onset (PAO) and age at onset (AAO) appears to be important for interpreting results of previous analyses of AAO in bipolar disorder (BD). Using an admixture analysis, we examined independently the distributions of age at first depressive and hypomanic/manic episodes in 379 BD I and II patients. Subsequently, we examined the association of PAO and AAO with specific clinical variables, using parametric and nonparametric analyses. Both depressive and manic onsets showed bimodal distributions. For depressive episodes, the means were: 18.5 +/- 4.1 (early onset) and 33.6 +/- 10.4 (late onset) years; and for manic episodes 18.9 +/- 3.3 (early onset) and 34.8 +/- 10.9 (late onset) years. For the overall AAO the best fit was for a mixture of three lognormal distributions (mean S.D.): 15.5 +/- 2.0, 22.8 +/- 4.6, and 36.1 +/- 10.1 years. Overall, an early onset was significantly associated with a chronic course of the disorder, a stronger family history of affective disorder, The interaction between polarity at onset (PAO) and age at onset (AAO) appears to be important for interpreting results of previous analyses of AAO in bipolar disorder (BD). Using an admixture analysis, we examined independently the distributions of age at first depressive and hypomanic/manic episodes in 379 BD I and II patients. Subsequently, we examined the association of PAO and AAO with specific clinical variables, using parametric and nonparametric analyses. Both depressive and manic onsets showed bimodal distributions. For depressive episodes, the means were: 18.5 +/- 4.1 (early onset) and 33.6 +/- 10.4 (late onset) years; and for manic episodes 18.9 +/- 3.3 (early onset) and 34.8 +/- 10.9 (late onset) years. For the overall AAO the best fit was for a mixture of three lognormal distributions (mean S.D.): 15.5 +/- 2.0, 22.8 +/- 4.6, and 36.1 +/- 10.1 years. Overall, an early onset was significantly associated with a chronic course of the disorder, a stronger family history of affective disorder, (en)
Title	An admixture analysis of the age at index episodes in bipolar disorder An admixture analysis of the age at index episodes in bipolar disorder (en)
skos:prefLabel	An admixture analysis of the age at index episodes in bipolar disorder An admixture analysis of the age at index episodes in bipolar disorder (en)
skos:notation	RIV/00216208:11120/11:00003507!RIV12-MSM-11120___
http://linked.open...avai/predkladatel	3. lékařská fakulta
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Růžičková, Martina Alda, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / 3. lékařská fakulta
http://linked.open...dnocenehoVysledku	185392
http://linked.open...ai/riv/idVysledku	RIV/00216208:11120/11:00003507
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	onset; bipolar; distributions; index episode; polarity (en)
http://linked.open.../riv/klicoveSlovo	onset bipolar distributions index episode polarity
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[59CCA99AAEE9]
http://linked.open...i/riv/nazevZdroje	Psychiatry Research
http://linked.open...in/vavai/riv/obor	FL
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	188
http://linked.open...iv/tvurceVysledku	Alda, Martin Ortiz, Abigail Růžičková, Martina
http://linked.open...ain/vavai/riv/wos	000291834900007
issn	0165-1781
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.psychres.2010.10.033
http://localhost/t...ganizacniJednotka	11120
is http://linked.open...avai/riv/vysledek of	An admixture analysis of the age at index episodes in bipolar disorder An admixture analysis of the age at index episodes in bipolar disorder

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