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  • Background and Aims: Pediatric ulcerative colitis (UC) shares many features with adult-onset disease but there are some unique considerations; therefore, therapeutic approaches have to be adapted to these particular needs. We aimed to formulate guidelines for managing UC in children based on a systematic review (SR) of the literature and a robust consensus process. The present article is a product of a joint effort of the European Crohn's and Colitis Organization (ECCO) and the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). Methods: A group of 27 experts in pediatric IBD participated in an iterative consensus process including 2 face-to-face meetings, following an open call to ESPGHAN and ECCO members. A list of 23 predefined questions were addressed by working subgroups based on a SR of the literature. Results: A total of 40 formal recommendations and 68 practice points were endorsed with a consensus rate of at least 89% regarding initial evaluation, how to monitor disease activity, the role of endoscopic evaluation, medical and surgical therapy, timing and choice of each medication, the role of combined therapy, and when to stop medications. A management flowchart, based on the Pediatric Ulcerative Colitis Activity Index (PUCAI), is presented. Conclusions: These guidelines provide clinically useful points to guide the management of UC in children. Taken together, the recommendations offer a standardized protocol that allows effective, timely management and monitoring of the disease course, while acknowledging that each patient is unique.
  • Background and Aims: Pediatric ulcerative colitis (UC) shares many features with adult-onset disease but there are some unique considerations; therefore, therapeutic approaches have to be adapted to these particular needs. We aimed to formulate guidelines for managing UC in children based on a systematic review (SR) of the literature and a robust consensus process. The present article is a product of a joint effort of the European Crohn's and Colitis Organization (ECCO) and the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). Methods: A group of 27 experts in pediatric IBD participated in an iterative consensus process including 2 face-to-face meetings, following an open call to ESPGHAN and ECCO members. A list of 23 predefined questions were addressed by working subgroups based on a SR of the literature. Results: A total of 40 formal recommendations and 68 practice points were endorsed with a consensus rate of at least 89% regarding initial evaluation, how to monitor disease activity, the role of endoscopic evaluation, medical and surgical therapy, timing and choice of each medication, the role of combined therapy, and when to stop medications. A management flowchart, based on the Pediatric Ulcerative Colitis Activity Index (PUCAI), is presented. Conclusions: These guidelines provide clinically useful points to guide the management of UC in children. Taken together, the recommendations offer a standardized protocol that allows effective, timely management and monitoring of the disease course, while acknowledging that each patient is unique. (en)
Title
  • Management of Pediatric Ulcerative Colitis: Joint ECCO and ESPGHAN Evidence-based Consensus Guidelines
  • Management of Pediatric Ulcerative Colitis: Joint ECCO and ESPGHAN Evidence-based Consensus Guidelines (en)
skos:prefLabel
  • Management of Pediatric Ulcerative Colitis: Joint ECCO and ESPGHAN Evidence-based Consensus Guidelines
  • Management of Pediatric Ulcerative Colitis: Joint ECCO and ESPGHAN Evidence-based Consensus Guidelines (en)
skos:notation
  • RIV/00064203:_____/12:8208!RIV13-MZ0-00064203
http://linked.open...avai/predkladatel
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 3
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http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
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  • 147980
http://linked.open...ai/riv/idVysledku
  • RIV/00064203:_____/12:8208
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • children; clinical guidelines; European Crohn's and Colitis Organization; European Society for Paediatric Gastroenterology; Hepatology, and Nutrition, management; Pediatric Ulcerative Colitis Activity Index; ulcerative colitis; inflammatory-bowel-disease; pouch-anal anastomosis; primary sclerosing cholangitis; placebo-controlled trial; randomized controlled-trial; oral 5-aminosalicylic acid; controlled multicenter trial; dose ursodeoxycholic acid; population-based cohort; bone-mineral density (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • US - Spojené státy americké
http://linked.open...ontrolniKodProRIV
  • [2A5C5275BF65]
http://linked.open...i/riv/nazevZdroje
  • Journal of Pediatric Gastroenterology and Nutrition
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 55
http://linked.open...iv/tvurceVysledku
  • Bronský, Jiří
  • Veres, G.
  • Cucchiara, S.
  • Dias, J. A.
  • Escher, JC
  • Hugot, J. P.
  • Koláček, S.
  • Levine, A.
  • Lionetti, P.
  • Staiano, A.
  • Turner, D.
  • Braegger, CP
  • Dignass, A.
  • Fagerberg, UL
  • Griffiths, A. M.
  • Hussey, S.
  • Kolho, KL
  • Pcerregaard, A.
  • Potapov, A.
  • Rintala, R.
  • Ruemmele, FM
  • Russell, RK
  • Serban, D. E.
  • Sweeny, B.
  • Veerman, G.
  • Wilson, DC
  • de Ridder, L.
http://linked.open...ain/vavai/riv/wos
  • 000308276900024
issn
  • 0277-2116
number of pages
is http://linked.open...avai/riv/vysledek of
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