About: HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study

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About: HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	DNA methylation of polycomb group target (PCGT) genes is an early step in carcinogenesis and could potentially be assayed to determine cancer risk prediction. To assess whether methylation changes in PCGT genes in normal tissue is able to predict the presence of cancer, we studied HOXA gene methylation in normal endometrium from premenopausal ovarian cancer patients and age-matched healthy controls without ovarian cancer. DNA methylation of HOXA9 and HOXA11 genes in normal endometrium was associated with ovarian cancer in an initial test set and this was subsequently confirmed in independent validation sample sets. DNA methylation of polycomb group target (PCGT) genes is an early step in carcinogenesis and could potentially be assayed to determine cancer risk prediction. To assess whether methylation changes in PCGT genes in normal tissue is able to predict the presence of cancer, we studied HOXA gene methylation in normal endometrium from premenopausal ovarian cancer patients and age-matched healthy controls without ovarian cancer. DNA methylation of HOXA9 and HOXA11 genes in normal endometrium was associated with ovarian cancer in an initial test set and this was subsequently confirmed in independent validation sample sets. (en)
Title	HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study (en)
skos:prefLabel	HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study (en)
skos:notation	RIV/00064165:_____/09:4602!RIV10-MZ0-00064165
http://linked.open...avai/riv/aktivita	N
http://linked.open...avai/riv/aktivity	N
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Zikán, Michal
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Všeobecná fakultní nemocnice v Praze / (nerozlišená součást)
http://linked.open...dnocenehoVysledku	317891
http://linked.open...ai/riv/idVysledku	RIV/00064165:_____/09:4602
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	ovarian cancer; methylation; HOXA; Mullerian duct; endometrium (en)
http://linked.open.../riv/klicoveSlovo	endometrium ovarian cancer methylation HOXA Mullerian duct
http://linked.open...odStatuVydavatele	CH - Švýcarská konfederace
http://linked.open...ontrolniKodProRIV	[9EBDF11455A3]
http://linked.open...i/riv/nazevZdroje	International Journal of Cancer
http://linked.open...in/vavai/riv/obor	FK
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	17 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	125
http://linked.open...iv/tvurceVysledku	Zikán, Michal Widschwendter, Martin Apostolidou, Sophia Arora, Rupali Ayhan, Ayse Fourkala, Evangelia O. Frasco, Melissa A. Jones, Allison A. Pearce, Celeste Leigh
http://linked.open...ain/vavai/riv/wos	000270750000029
issn	0020-7136
number of pages	5 (xsd:int)
is http://linked.open...avai/riv/vysledek of	HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: A proof of principle study

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