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| Description
| - This research project concerns syntheses of the novel carbocyclic nucleoside analogues in which the sugar portion is replaced with hydroxy- and dihydroxy(hydroxymethyl)bicyclo[2.2.1]heptanes. The resulting compounds will be routinely screened against selected RNA and DNA viruses, as well as against HIV 1 and HIV 2, and tested for cytostatic activity. (en)
- Tento výzkumný projekt je zaměřen na synthesy nových karbocyklických analogů nukleosidů, ve kterých je cukerná část nahrazena hydroxy- a dihydroxy(hydroxymethyl)bicyklo[2.2.1]heptany. Připravené látky budou testovány na vybraných RNK a DNK virech, včetněHIV-1 a HIV-2 a budou rovněž testovány na cytostatickou aktivitu.
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| Title
| - Carbocyclic nucleoside analogues containing substituted norbornanes: compounds with potential biological effects (en)
- Karbocyklická analoga nukleosidů obsahující substituované norbornany: látky s potenciálními biologickými účinky
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| skos:notation
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| http://linked.open...avai/cep/aktivita
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| http://linked.open...kovaStatniPodpora
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| http://linked.open...ep/celkoveNaklady
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| http://linked.open...datumDodatniDoRIV
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| http://linked.open...i/cep/druhSouteze
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| http://linked.open...ep/duvernostUdaju
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| http://linked.open.../cep/fazeProjektu
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| http://linked.open...ai/cep/hlavniObor
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| http://linked.open...hodnoceniProjektu
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| http://linked.open...vai/cep/kategorie
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| http://linked.open.../cep/klicovaSlova
| - carbocyclic nucleosides; norbornane; bicyclo[2.2.1]heptane; antivirals; cytostatics (en)
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| http://linked.open...ep/partnetrHlavni
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| http://linked.open...inujicichPrijemcu
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| http://linked.open...cep/pocetPrijemcu
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| http://linked.open...ocetSpoluPrijemcu
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| http://linked.open.../pocetVysledkuRIV
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| http://linked.open...enychVysledkuVRIV
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| http://linked.open...lneniVMinulemRoce
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| http://linked.open.../prideleniPodpory
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| http://linked.open...iciPoslednihoRoku
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| http://linked.open...atUdajeProjZameru
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| http://linked.open.../vavai/cep/soutez
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| http://linked.open...usZobrazovaneFaze
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| http://linked.open...ai/cep/typPojektu
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| http://linked.open...ep/ukonceniReseni
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| http://linked.open...ep/zahajeniReseni
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| http://linked.open...jektu+dodavatelem
| - Novel racemic carbocyclic nucleoside analogues derived from 5,5- and 6,6-bis(hydroxymethyl)bicyclo[2.2.1]heptan-2-ols, 3-(hydroxymethyl)bicyclo[2.2.1]heptane-2,5-diol, 2- and 3-(hydroxymethyl)bicyclo[2.2.1]heptane, and 5- or 6-(hydroxymethyl)bicyclo[2.2. (en)
- V rámci projektu byla syntetizována nová racemická karbocyklická anloga nukleosidů odvozená od 5,5- a 6,6-bis(hydroxymethyl)bicyklo[2.2.1]heptan-2-olů, 3-(hydroxymethyl)bicyklo[2.2.1]heptan-2,5-diolu, 2- a 3-(hydroxymethyl)bicyklo[2.2.1]heptanů a 5- a 6- (cs)
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| http://linked.open...tniCyklusProjektu
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| http://linked.open.../cep/klicoveSlovo
| - antivirals
- bicyclo[2.2.1]heptane
- norbornane
- carbocyclic nucleosides
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| is http://linked.open...vavai/riv/projekt
of | |
| is http://linked.open...vavai/cep/projekt
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