About: Synthetic approach to eicosanoids. (New syntheses for production of PROSTANOIDS).     Goto   Sponge   NotDistinct   Permalink

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Description
  • Intensification of existing modular syntesis of prostanoids by focussing of the research to weak points - well defined synthetic operations. New synthetic sequences applied to synthesis of generic drug LATANOPROST for application in ophthalmology. Application of transition metal catalyzed reactions in the synthesis of prostanoids. (en)
  • Intenzifikace stávající kodulární syntézy prostanoidů soustředěním výzkumu na vytipovaná úzká místa - vybrané jednotlivé operace. Návrh a vyřešení nové syntetické sekvence pro syntézu generického léčiva LATANOPROST pro chemoterapii očních chorob. Aplikace tranzitními kovy katalyzovaných reakcí do syntéz prostanoidů.
Title
  • Synthetic approach to eicosanoids. (New syntheses for production of PROSTANOIDS). (en)
  • Syntetické přístupy k eikosanoidům. (Nové syntézy a výrobní postupy PROSTANOIDU).
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  • FT-TA2/083
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  • eicosanoids; prostaglandins; synthetic drugs; organic synthesis; generic drugs (en)
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  • Provedena úprava postupu chromatografické separace S+R ENOL-D, dořešena syntéza, technologizace a zavedení do výroby TRAVOPROSTU, optimalizace a dořešení laboratorní technologie LATANOPROSTU do intermidiátu HYDOXYKYSELINA-L. (cs)
  • Modification of a procedure for chromatographic separation of S+R-ENOL-D, technologic arrangement of TRAVOPROST, the technology of LATANOPROST in laboratory scale up to intermediate HYDROXYACID-L was solved. (en)
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  • eicosanoids
  • organic synthesis
  • prostaglandins
  • synthetic drugs
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