About: TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors.

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About: TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Susceptibility of primary malignant and normal hematopoietic progenitors to TRAIL-induced apoptosis was studied by clonogenic assays and by their repopulating potential after transplantation into NOD/SCID mice. In E. coli produced extacellular part of human TRAIL (Aas 95-281) significantly reduced the number of myeloid colonies (CFU-GM) and clusters from patients with AML, CML, and MDS szndromes bud did not inhibited in vitro and in vivo growth of normal hematopoietic progenitors and stem cells. Susceptibility of primary malignant and normal hematopoietic progenitors to TRAIL-induced apoptosis was studied by clonogenic assays and by their repopulating potential after transplantation into NOD/SCID mice. In E. coli produced extacellular part of human TRAIL (Aas 95-281) significantly reduced the number of myeloid colonies (CFU-GM) and clusters from patients with AML, CML, and MDS szndromes bud did not inhibited in vitro and in vivo growth of normal hematopoietic progenitors and stem cells. (en)
Title	TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. (en)
skos:prefLabel	TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. (en)
skos:notation	RIV/68378050:_____/02:23010500!RIV/2003/AV0/A23003/N
http://linked.open.../vavai/riv/strany	67;73
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA301/99/0350), P(GV301/98/K042), P(IAA5052001), Z(AV0Z5052915)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Anděra, Ladislav
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav molekulární genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	667205
http://linked.open...ai/riv/idVysledku	RIV/68378050:_____/02:23010500
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	TRAIL; - leukemia; - apoptosis (en)
http://linked.open.../riv/klicoveSlovo	TRAIL - leukemia - apoptosis
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D4B9CAC06B79]
http://linked.open...i/riv/nazevZdroje	Leukemia
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Screening for and characterization of novel, apoptosis inducing surface molecules of human hematopoietic cells Acute monoblastic leukaemia: Analysis of molecular mechanisms and possibilities of targeted regulation Characterization and potential therapeutical use of TRAIL-mediated apoptosis
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	16
http://linked.open...iv/tvurceVysledku	Anděra, Ladislav Neuwirtová, R. Stopka, T. Nečas, E. Živný, J. Čermák, J. Jelínek, J. Plašilová, M.
http://linked.open...n/vavai/riv/zamer	Regulace a signální cesty uplatňující se v genové expresi, imunitě, onkogenezi, replikaci virů, tvorbě buněčných struktur, chování buněk, vývoji a oplození
issn	0887-6924
number of pages	7 (xsd:int)

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