About: Temporal regulation of Drosophila salivary gland degeneration by the Broad-Complex transcription factors.

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About: Temporal regulation of Drosophila salivary gland degeneration by the Broad-Complex transcription factors. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The destruction of obsolete larval tissues at the onset of insect metamorphosis is a complex process triggered by the steroid hormone ecdysone. The reduced bristels on palpus (rbp) gene of the Broad-Complex (BR-C) locus plays a critical role in salivary gland (SG) degeneration. The BR-C locus encodes four major protein isoforms, including BR-C Z1, Z2, Z3, and Z4. We used transgenes expressing each of the four major BR-C isoform proteins and revealed that, depending upon the period of expression relative to the major peak of ecdysone production, BR-C Z1, Z2,and Z4 first inhibited and then stimulated the process of SG degeneration. In contrast, BR-C Z3 exerted all time points an inhibition on SG degeneration. The destruction of obsolete larval tissues at the onset of insect metamorphosis is a complex process triggered by the steroid hormone ecdysone. The reduced bristels on palpus (rbp) gene of the Broad-Complex (BR-C) locus plays a critical role in salivary gland (SG) degeneration. The BR-C locus encodes four major protein isoforms, including BR-C Z1, Z2, Z3, and Z4. We used transgenes expressing each of the four major BR-C isoform proteins and revealed that, depending upon the period of expression relative to the major peak of ecdysone production, BR-C Z1, Z2,and Z4 first inhibited and then stimulated the process of SG degeneration. In contrast, BR-C Z3 exerted all time points an inhibition on SG degeneration. (en)
Title	Temporal regulation of Drosophila salivary gland degeneration by the Broad-Complex transcription factors. Temporal regulation of Drosophila salivary gland degeneration by the Broad-Complex transcription factors. (en)
skos:prefLabel	Temporal regulation of Drosophila salivary gland degeneration by the Broad-Complex transcription factors. Temporal regulation of Drosophila salivary gland degeneration by the Broad-Complex transcription factors. (en)
skos:notation	RIV/68378041:_____/02:19023087!RIV/2003/GA0/A19003/N
http://linked.open.../vavai/riv/strany	67;78
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA304/02/0342), Z(AV0Z5039906), Z(MSM 111100003)
http://linked.open...iv/cisloPeriodika	N/A
http://linked.open...vai/riv/dodaniDat	2003
http://linked.open...aciTvurceVysledku	Raška, Ivan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální medicíny AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	666580
http://linked.open...ai/riv/idVysledku	RIV/68378041:_____/02:19023087
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	programmed cell death; BR-C transcription factors; drosophila (en)
http://linked.open.../riv/klicoveSlovo	drosophila programmed cell death BR-C transcription factors
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[C4382E770188]
http://linked.open...i/riv/nazevZdroje	Journal of Structural Biology
http://linked.open...in/vavai/riv/obor	EA
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Functions and molecular interactions of DOA protein kinase in signal transduction during Drosophila development.
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	140
http://linked.open...iv/tvurceVysledku	Raška, Ivan Kuchárová-Mahmood, S. Farkaš, R. Mechler, B. M.
http://linked.open...n/vavai/riv/zamer	The molecular and cellular basis of selected human diseases, mechanisms of normal and pathological function, principles of diagnosis and therapy http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20111100003
issn	1047-8477
number of pages	12 (xsd:int)

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