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Description
| - TNF-alpha is known to play a major role in liver regeneration as well as in carcinogenesis. We investigated possible interaction of TNF-alpha with ligands of the AhR. TNF-alpha significantly potentiated proliferative effects of TCDD and PCB126 leading to an increased percentage of cells in S-phase of cell cycle and increased expression of cyclin A. TNF-alpha inhibited AhR-dependent induction of CYP1A1, in contrast, it enhanced induction of CYP1B1.
- TNF-alpha is known to play a major role in liver regeneration as well as in carcinogenesis. We investigated possible interaction of TNF-alpha with ligands of the AhR. TNF-alpha significantly potentiated proliferative effects of TCDD and PCB126 leading to an increased percentage of cells in S-phase of cell cycle and increased expression of cyclin A. TNF-alpha inhibited AhR-dependent induction of CYP1A1, in contrast, it enhanced induction of CYP1B1. (en)
- TNF-alfa hraje důležitou roli během procesu jaterní regenerace, stejně jako při vzniku karcinogeneze. V této práci se zabýváme možnou interakcí TNF-alfa s ligandy AhR. TNF-alfa významně posiluje proliferační účinky TCDD a PCB126, což vede ke zvýšení procenta buněk v S-fázi buněčného cyklu a zvýšenou expresi cyklinu A. TNF-alfa inhibuje AhR-dependentní indukci CYP1A1 a naopak posiluje expresi CYP1B1. (cs)
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Title
| - Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells
- Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells (en)
- TNF-alfa se podílí na proliferaci a změně exprese enzymů cytochromu P450 indukovaných působením ligandů Ah receptoru u potkaních jaterních buněk (cs)
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skos:prefLabel
| - Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells
- Tumor necrosis factor-alpha modulates effects of aryl hydrocarbon receptor ligands on cell proliferation and expression of cytochrome P450 enzymes in rat liver %22stem-like%22 cells (en)
- TNF-alfa se podílí na proliferaci a změně exprese enzymů cytochromu P450 indukovaných působením ligandů Ah receptoru u potkaních jaterních buněk (cs)
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skos:notation
| - RIV/68081707:_____/07:00085551!RIV08-AV0-68081707
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GA524/05/0595), Z(AV0Z50040507), Z(AV0Z50040702)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/68081707:_____/07:00085551
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - tumor necrosis factor-alpha; xenobiotic metabolizing enzymes; dioxin (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Kozubík, Alois
- Krčmář, P.
- Machala, M.
- Umannová, Lenka
- Vondráček, Jan
- Zatloukalová, Jiřina
- Májková, Z.
- Hennig, B.
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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