About: Some biological actions of PEG-conjugated RNase A oligomers

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Publikovali jsme již, že numerická RNase A nemá žádné významné biologické aktivity, zatímco oligomery tohoto enzymu prokázaly pozoruhodné aspermatogenní a protinádorové působení. Rovněž bylo prokázáno, že chemická vazba nativní RNase A na PEG signifikatně zapůsobila antitumorově a aspermatogenně. V této práci jsme prokázali, že chemická vazba PEg a RNase A C-dimerem a trimerem snižuje aspermatogenní působení těchto komplexů. Na druhé straně se protinádorové působení na růst humánního UB 900518 melanomu rostoucího na athmických myších zvyšovalo. (cs) We have already shown that monomeric RNase A has no significant biological activity, whereas its oligomers (dimer to tetromer) show remarkable aspermatogenic and antitumour activities. Furthermore, conjugates prepared by chemical binding of native RNase A to polyethylene glycol (PEG) have shown a significant antitumour and aspermatogenic effects. In this work it was found that the chemical conjugation of PEG to the RNase A C-dimer, and to the RNase A trimers decreases the aspermatogenic activity of the oligomers while increasing their inhibitory activity on the growth of the human UB 900518 amelanotic melanoma transplanted in athymic nusle mice. We have already shown that monomeric RNase A has no significant biological activity, whereas its oligomers (dimer to tetromer) show remarkable aspermatogenic and antitumour activities. Furthermore, conjugates prepared by chemical binding of native RNase A to polyethylene glycol (PEG) have shown a significant antitumour and aspermatogenic effects. In this work it was found that the chemical conjugation of PEG to the RNase A C-dimer, and to the RNase A trimers decreases the aspermatogenic activity of the oligomers while increasing their inhibitory activity on the growth of the human UB 900518 amelanotic melanoma transplanted in athymic nusle mice. (en)
Title	Some biological actions of PEG-conjugated RNase A oligomers Some biological actions of PEG-conjugated RNase A oligomers (en) PEGemi vázané RNase A oligomery a jejich některé biologické aktivity (cs)
skos:prefLabel	Some biological actions of PEG-conjugated RNase A oligomers Some biological actions of PEG-conjugated RNase A oligomers (en) PEGemi vázané RNase A oligomery a jejich některé biologické aktivity (cs)
skos:notation	RIV/67985904:_____/06:00040937!RIV07-AV0-67985904
http://linked.open.../vavai/riv/strany	79;85
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA523/04/0755), P(NR8233), Z(AV0Z50450515)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2007
http://linked.open...aciTvurceVysledku	Slavík, Tomáš Matoušek, Josef
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav živočišné fyziologie a genetiky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	500308
http://linked.open...ai/riv/idVysledku	RIV/67985904:_____/06:00040937
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	RNase A oligomers; polyethylene glycol conjugates; anti-tumour activity (en)
http://linked.open.../riv/klicoveSlovo	RNase A oligomers anti-tumour activity polyethylene glycol conjugates
http://linked.open...odStatuVydavatele	SK - Slovenská republika
http://linked.open...ontrolniKodProRIV	[7609EB33B7AD]
http://linked.open...i/riv/nazevZdroje	Neoplasma
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Biological and antitumor effects of pancreatic ribonuclease A oligomers Targeted experimental therapy of leukemia by the specific action of antireceptor monoclonal antibodies
http://linked.open...UplatneniVysledku	2006
http://linked.open...v/svazekPeriodika	53
http://linked.open...iv/tvurceVysledku	Poučková, P. Matoušek, Josef Škvor, J. Slavík, Tomáš Souček, J. Gotte, G. Libonati, M. Vottariello, F. Laurents, D. V.
http://linked.open...n/vavai/riv/zamer	Genetic, functional and developmental potential of animal cells, tissues and organisms: their use in medicine, ecology and agriculture
issn	0028-2685
number of pages	7 (xsd:int)

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