About: Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter     Goto   Sponge   NotDistinct   Permalink

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  • Disruption of BMH1 in S. cerevisiae, encoding the major 14-3-3 isoform, resulted in an increased sensitivity to Na+, Li+ and K+ and to cationic drugs. BMH1 deletion did not affect plasma membrane potential. Testing the genetic interaction between BMH genes and genes encoding five plasma-membrane potassium and sodium transporters revealed, that 14-3-3 proteins neither interact with the potassium uptake systems, nor with the potassium-specific channel nor with the Na+(K+)-ATPases. Instead, a genetic interaction was identified between BMH1 and NHA1 which encodes an Na+(K+)/H+ antiporter
  • Disruption of BMH1 in S. cerevisiae, encoding the major 14-3-3 isoform, resulted in an increased sensitivity to Na+, Li+ and K+ and to cationic drugs. BMH1 deletion did not affect plasma membrane potential. Testing the genetic interaction between BMH genes and genes encoding five plasma-membrane potassium and sodium transporters revealed, that 14-3-3 proteins neither interact with the potassium uptake systems, nor with the potassium-specific channel nor with the Na+(K+)-ATPases. Instead, a genetic interaction was identified between BMH1 and NHA1 which encodes an Na+(K+)/H+ antiporter (en)
Title
  • Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter
  • Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter (en)
skos:prefLabel
  • Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter
  • Yeast 14-3-3 proteins participate in the regulation of cell cation homeostasis via interaction with Nha1 alkali-metal-cation/proton antiporter (en)
skos:notation
  • RIV/67985823:_____/12:00377359!RIV13-AV0-67985823
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I, P(IAA500110801), P(LC531), P(OC10012), Z(AV0Z50110509)
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  • 7
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  • 181235
http://linked.open...ai/riv/idVysledku
  • RIV/67985823:_____/12:00377359
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  • yeast; 14-3-3 proteins; ion homeostasis; Nha1 antiporter (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
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  • [6B98DB9795DB]
http://linked.open...i/riv/nazevZdroje
  • Biochimica et Biophysica Acta. General Subjects
http://linked.open...in/vavai/riv/obor
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  • 1820
http://linked.open...iv/tvurceVysledku
  • Sychrová, Hana
  • Zahrádka, Jaromír
  • Van Heusden, G.P.H.
http://linked.open...ain/vavai/riv/wos
  • 000305366100007
http://linked.open...n/vavai/riv/zamer
issn
  • 0304-4165
number of pages
http://bibframe.org/vocab/doi
  • 10.1016/j.bbagen.2012.03.013
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