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Description
  • Hot-melt extrusion (HME), originally coming from plastic industry, becomes at present an interesting technology also in the pharmaceutical field. The number of drugs with poor solubility and also bioavailability is increasing. In addition, most of the organic drugs are exhibiting polymorphism. Together with the utilization of appropriate carriers and other excipients, HME introduces an interesting possibility how to increase the solubility of poorly soluble drugs or protect unwanted polymorphic changes and how to improve bioavailability of problematic drugs. HME can also be used in the formation of dosage forms with controlled drug release, e.g. pellets or films. It is a relative inexpensive, efficient and reproducible technology, a solvent free and drug-friendly process. This article is an overview of possible utilization of this modern technology in the pharmaceutical field.
  • Hot-melt extrusion (HME), originally coming from plastic industry, becomes at present an interesting technology also in the pharmaceutical field. The number of drugs with poor solubility and also bioavailability is increasing. In addition, most of the organic drugs are exhibiting polymorphism. Together with the utilization of appropriate carriers and other excipients, HME introduces an interesting possibility how to increase the solubility of poorly soluble drugs or protect unwanted polymorphic changes and how to improve bioavailability of problematic drugs. HME can also be used in the formation of dosage forms with controlled drug release, e.g. pellets or films. It is a relative inexpensive, efficient and reproducible technology, a solvent free and drug-friendly process. This article is an overview of possible utilization of this modern technology in the pharmaceutical field. (en)
Title
  • Hot-melt extrusion
  • Hot-melt extrusion (en)
skos:prefLabel
  • Hot-melt extrusion
  • Hot-melt extrusion (en)
skos:notation
  • RIV/62157124:16370/12:43871258!RIV13-MSM-16370___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
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  • 139643
http://linked.open...ai/riv/idVysledku
  • RIV/62157124:16370/12:43871258
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  • hot-melt extrusion, equipment, excipients, pellets, films (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [2780BF53D4BA]
http://linked.open...i/riv/nazevZdroje
  • Česká a slovenská farmacie
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http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 61
http://linked.open...iv/tvurceVysledku
  • Rabišková, Miloslava
  • Šalandová, Jana
issn
  • 1210-7816
number of pages
http://localhost/t...ganizacniJednotka
  • 16370
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