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rdf:type
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Description
| - In 2008, the World Health Organization (WHO) revised its classification of hematopoietic neoplasms and new %22acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)%22 was defined as !AML arising from a previous MDS or MDS/MPN, AML with an MDS-related cytogenetic abnormality, and/or AML-MLD changes, mainly with a complex karyotype! (1). Myelodyplastic syndrome (MDS)-related chromosomal changes involve mainly aberrations of chromosomes 5, 7, and a complex karyotype. The change from ploidy to tetraploidy (4n) is a rare chromosomal abnormality in AML, and only a few cases have been described in the literature (2,3). Despite its rarity in AML, tetraploidization can initiate chromosomal instability (CIN) and promote cell transformation (4,5). Presented here is a case of a 52-year-old male with an initial diagnosis of AML-MRC with tetraploid clones detected in his bone marrow. FISH analysis revealed a large deleted derivative chromosome 5 within a complex caryotype. To the best of our knowledge, such findings in AML-MRC have not yet been reported in the literature.
- In 2008, the World Health Organization (WHO) revised its classification of hematopoietic neoplasms and new %22acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)%22 was defined as !AML arising from a previous MDS or MDS/MPN, AML with an MDS-related cytogenetic abnormality, and/or AML-MLD changes, mainly with a complex karyotype! (1). Myelodyplastic syndrome (MDS)-related chromosomal changes involve mainly aberrations of chromosomes 5, 7, and a complex karyotype. The change from ploidy to tetraploidy (4n) is a rare chromosomal abnormality in AML, and only a few cases have been described in the literature (2,3). Despite its rarity in AML, tetraploidization can initiate chromosomal instability (CIN) and promote cell transformation (4,5). Presented here is a case of a 52-year-old male with an initial diagnosis of AML-MRC with tetraploid clones detected in his bone marrow. FISH analysis revealed a large deleted derivative chromosome 5 within a complex caryotype. To the best of our knowledge, such findings in AML-MRC have not yet been reported in the literature. (en)
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Title
| - Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)
- Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR) (en)
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skos:prefLabel
| - Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR)
- Rare tetraploidy with large 5q deletion in acute myeloid leukemia with myelodysplasia-related changes (AML-MCR) (en)
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skos:notation
| - RIV/61989592:15110/12:33138480!RIV13-MSM-15110___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/61989592:15110/12:33138480
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - FISH analysis; chromosomal changes; myelodysplastic syndrome (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Hubáček, Jaromír
- Indrák, Karel
- Jarošová, Marie
- Katrincsáková, Beáta
- Pikalová, Zuzana
- Papajík, Tomáš
- Holzerová, Milena
- Nedomová, Radka
- Mičková, Pavla
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.leukres.2011.12.014
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http://localhost/t...ganizacniJednotka
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