About: The plant formin AtFH4 interacts with both actin and microtubules, and contains a newly identified microtubule-binding domain

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The dynamic behaviour of the actin cytoskeleton in plants relies on the coordinated action of several classes of actin-binding proteins (ABPs). These ABPs include the plant-specific subfamilies of actin-nucleating formin proteins. The model plant species Arabidopsis thaliana has over 20 formin proteins, all of which contain plant-specific regions in place of the GTPase-binding domain, formin homology (FH)3 domain, and DAD and DID motifs found in many fungal and animal formins. We have identified for the first time a plant-specific region of the membrane-integrated formin AtFH4 that mediates an association with the microtubule cytoskeleton. In vitro analysis shows that this region (named the GOE domain) binds directly to microtubules. Overexpressed AtFH4 accumulates at the endoplasmic reticulum membrane and co-aligns the endoplasmic reticulum with microtubules. The FH1 and FH2 domains of formins are conserved in plants, and we show that these domains of AtFH4 nucleate F-actin. The dynamic behaviour of the actin cytoskeleton in plants relies on the coordinated action of several classes of actin-binding proteins (ABPs). These ABPs include the plant-specific subfamilies of actin-nucleating formin proteins. The model plant species Arabidopsis thaliana has over 20 formin proteins, all of which contain plant-specific regions in place of the GTPase-binding domain, formin homology (FH)3 domain, and DAD and DID motifs found in many fungal and animal formins. We have identified for the first time a plant-specific region of the membrane-integrated formin AtFH4 that mediates an association with the microtubule cytoskeleton. In vitro analysis shows that this region (named the GOE domain) binds directly to microtubules. Overexpressed AtFH4 accumulates at the endoplasmic reticulum membrane and co-aligns the endoplasmic reticulum with microtubules. The FH1 and FH2 domains of formins are conserved in plants, and we show that these domains of AtFH4 nucleate F-actin. (en)
Title	The plant formin AtFH4 interacts with both actin and microtubules, and contains a newly identified microtubule-binding domain The plant formin AtFH4 interacts with both actin and microtubules, and contains a newly identified microtubule-binding domain (en)
skos:prefLabel	The plant formin AtFH4 interacts with both actin and microtubules, and contains a newly identified microtubule-binding domain The plant formin AtFH4 interacts with both actin and microtubules, and contains a newly identified microtubule-binding domain (en)
skos:notation	RIV/61389030:_____/10:00350394!RIV11-GA0-61389030
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GAP305/10/0433), P(LC06004), S, Z(AV0Z50380511), Z(MSM0021620858)
http://linked.open...iv/cisloPeriodika	8
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Žárský, Viktor Fendrych, Matyáš
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav experimentální botaniky AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	279084
http://linked.open...ai/riv/idVysledku	RIV/61389030:_____/10:00350394
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Actin regulating proteins; Membrane; Microtubule (en)
http://linked.open.../riv/klicoveSlovo	Membrane Microtubule Actin regulating proteins
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[AEF29975E6AC]
http://linked.open...i/riv/nazevZdroje	Journal of Cell Science
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Integration of research activities to study the plant genome Characterization of selected representatives of novel plant Class II and Class III formin families
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	123
http://linked.open...iv/tvurceVysledku	Žárský, Viktor Fendrych, Matyáš Cvrčková, F. Bell, K. S. Deeks, M. J. Hussey, P. J. Oparka, K. Smertenko, A.
http://linked.open...ain/vavai/riv/wos	000276568200004
http://linked.open...n/vavai/riv/zamer	Mechanismy regulace růstu a vývoje rostlin na úrovni buněk, orgánů a celých organismů: fyziologické, genetické a molekulárně biologické základy Signaling and cellular response mechanisms
issn	0021-9533
number of pages	7 (xsd:int)

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