About: Click chemistry as a powerful and chemoselective tool for the attachment of targeting ligands to polymer drug carriers

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About: Click chemistry as a powerful and chemoselective tool for the attachment of targeting ligands to polymer drug carriers Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Various click chemistry azide–alkyne cycloaddition reactions were used to attach azide group-terminated peptides to polymer drug carriers in an effort to conjugate biologically active molecules with polymer drug carriers by directly binding unprotected peptides to these polymers. Three methods using click chemistry to conjugate the azide group-containing molecules with synthetic polymers were compared: (1) click chemistry with a Cu(I) catalyst in aqueous and organic solvents, (2) click reactions using ruthenium complex catalysts in DMF and (3) metal-free click chemistry based on a dibenzocyclooctyne (DBCO) reactive group. The suitability of these reactions was verified for the non-covalent attachment of targeting moieties to these polymer carriers via peptide–peptide interactions. Moreover, RAFT polymerization was suggested for the synthesis of semitelechelic copolymers containing a single DBCO group at the polymer chain end and for the preparation of well-defined diblock copolymer drug carriers consisting of specific peptide and hydrophilic polymer blocks. Various click chemistry azide–alkyne cycloaddition reactions were used to attach azide group-terminated peptides to polymer drug carriers in an effort to conjugate biologically active molecules with polymer drug carriers by directly binding unprotected peptides to these polymers. Three methods using click chemistry to conjugate the azide group-containing molecules with synthetic polymers were compared: (1) click chemistry with a Cu(I) catalyst in aqueous and organic solvents, (2) click reactions using ruthenium complex catalysts in DMF and (3) metal-free click chemistry based on a dibenzocyclooctyne (DBCO) reactive group. The suitability of these reactions was verified for the non-covalent attachment of targeting moieties to these polymer carriers via peptide–peptide interactions. Moreover, RAFT polymerization was suggested for the synthesis of semitelechelic copolymers containing a single DBCO group at the polymer chain end and for the preparation of well-defined diblock copolymer drug carriers consisting of specific peptide and hydrophilic polymer blocks. (en)
Title	Click chemistry as a powerful and chemoselective tool for the attachment of targeting ligands to polymer drug carriers Click chemistry as a powerful and chemoselective tool for the attachment of targeting ligands to polymer drug carriers (en)
skos:prefLabel	Click chemistry as a powerful and chemoselective tool for the attachment of targeting ligands to polymer drug carriers Click chemistry as a powerful and chemoselective tool for the attachment of targeting ligands to polymer drug carriers (en)
skos:notation	RIV/61389013:_____/14:00424588!RIV14-AV0-61389013
http://linked.open...avai/riv/aktivita	I
http://linked.open...avai/riv/aktivity	I
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Ulbrich, Karel Pechar, Michal Braunová, Alena Pola, Robert Laga, Richard
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Ústav makromolekulární chemie AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	7489
http://linked.open...ai/riv/idVysledku	RIV/61389013:_____/14:00424588
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	click chemistry; RAFT polymerization; hydrophilic polymers (en)
http://linked.open.../riv/klicoveSlovo	click chemistry RAFT polymerization hydrophilic polymers
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[D26E0D61CACE]
http://linked.open...i/riv/nazevZdroje	Polymer Chemistry
http://linked.open...in/vavai/riv/obor	CD
http://linked.open...ichTvurcuVysledku	5 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...UplatneniVysledku	2014
http://linked.open...v/svazekPeriodika	5
http://linked.open...iv/tvurceVysledku	Laga, Richard Pechar, Michal Pola, Robert Ulbrich, Karel Braunová, Alena
http://linked.open...ain/vavai/riv/wos	000331343100026
issn	1759-9954
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1039/C3PY01376F

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