About: Aorta remodelling associated with calcitonin gene related peptide concentration in rats with arterial hypertension

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About: Aorta remodelling associated with calcitonin gene related peptide concentration in rats with arterial hypertension Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Long-term hypertension in arteries leads to remodelling of the arterial wall. We focused on morphological changes in the wall of the subrenal aorta in rats suffering from arterial hypertension and chronic renal failure induced by 5/6 nephrectomy (NX). We quantified the area of the profile of the arterial lumen, the volume fraction of elastin and smooth muscle cells (SMC) in the tunica media, the thickness of the intima-media, the length density of elastin lamellae, the lamellar unit thickness and the lamellar number. Calcitonin gene related peptide (CGRP) was assayed in extracts of aortic tissue and in plasma. Ten days after the subtotal nephrectomy, the structure of the aorta of NX rats did not differ compared to control animals. Pronounced structural changes were observed ten weeks after 5/6 nephrectomy. The area of the lumen profile, the elastin volume fraction and the elastin lamellar number in the tunica media were all significantly higher (p < 0.001) in NX than in control animals. The SMC vo Long-term hypertension in arteries leads to remodelling of the arterial wall. We focused on morphological changes in the wall of the subrenal aorta in rats suffering from arterial hypertension and chronic renal failure induced by 5/6 nephrectomy (NX). We quantified the area of the profile of the arterial lumen, the volume fraction of elastin and smooth muscle cells (SMC) in the tunica media, the thickness of the intima-media, the length density of elastin lamellae, the lamellar unit thickness and the lamellar number. Calcitonin gene related peptide (CGRP) was assayed in extracts of aortic tissue and in plasma. Ten days after the subtotal nephrectomy, the structure of the aorta of NX rats did not differ compared to control animals. Pronounced structural changes were observed ten weeks after 5/6 nephrectomy. The area of the lumen profile, the elastin volume fraction and the elastin lamellar number in the tunica media were all significantly higher (p < 0.001) in NX than in control animals. The SMC vo (en)
Title	Aorta remodelling associated with calcitonin gene related peptide concentration in rats with arterial hypertension Aorta remodelling associated with calcitonin gene related peptide concentration in rats with arterial hypertension (en)
skos:prefLabel	Aorta remodelling associated with calcitonin gene related peptide concentration in rats with arterial hypertension Aorta remodelling associated with calcitonin gene related peptide concentration in rats with arterial hypertension (en)
skos:notation	RIV/49777513:23520/09:00501877!RIV10-MSM-23520___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0510), P(GA106/09/0734), Z(MSM0021620819), Z(MSM4977751303)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kochová, Petra Tonar, Zbyněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Západočeská univerzita v Plzni / Fakulta aplikovaných věd
http://linked.open...dnocenehoVysledku	303574
http://linked.open...ai/riv/idVysledku	RIV/49777513:23520/09:00501877
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	histology; stereology; chronic renal failure; nephrectomy; quantitative microscopy (en)
http://linked.open.../riv/klicoveSlovo	histology quantitative microscopy nephrectomy stereology chronic renal failure
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[6DA2926C844F]
http://linked.open...i/riv/nazevZdroje	Acta Veterinaria Brno
http://linked.open...in/vavai/riv/obor	EA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Relation among microscopic arrangement of biological tissues, function of cytoskeleton, and mechanical properties of living Centre for cardiovascular research
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	78
http://linked.open...iv/tvurceVysledku	Kochová, Petra Kuncová, Jitka Tonar, Zbyněk Švíglerová, Jitka Štengl, Milan Matějka, Vít M.
http://linked.open...n/vavai/riv/zamer	Náhrada a podpora funkce některých životně důležitých orgánů Predikce poruch heterogenních materiálů, komponent mechanických a biomechanických systémů.
issn	0001-7213
number of pages	8 (xsd:int)
http://localhost/t...ganizacniJednotka	23520

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