Attributes | Values |
---|
rdf:type
| |
Description
| - Molecular dynamics (MD) simulations of Kink-turn (K-turn) RNA motifs reveal hinge-like motions on the nano-second (ns) timescale. K-turn motifs are asymmetric internal loops found at conserved positions in the 16S and 23S ribosomal RNAs, and characterized by sharp bends in both phosphodiester backbones producing V-shaped structures. The bend is stabilized by non-Watson-Crick basepairs involving the minor (shallow) grooves of the helices. We have carried out a set of explicit-solvent MD simulations for selected K-turn motifs from 23S ribosomal RNA, Kt-38 (located at the base of the A-site finger), Kt-42 (located at the base of the L7/L12 stalk in the factor-binding site) and Kt-58 (located in Domain III). On a nano-second timescale, K-turns sample isoenergetic conformational substates. The simulations reveal the presence of long-residency sites for water, one of which is located close to the sharp turn of the phosphodiester backbones and, when occupied, mediates minor-groove interactions between the st
- Molecular dynamics (MD) simulations of Kink-turn (K-turn) RNA motifs reveal hinge-like motions on the nano-second (ns) timescale. K-turn motifs are asymmetric internal loops found at conserved positions in the 16S and 23S ribosomal RNAs, and characterized by sharp bends in both phosphodiester backbones producing V-shaped structures. The bend is stabilized by non-Watson-Crick basepairs involving the minor (shallow) grooves of the helices. We have carried out a set of explicit-solvent MD simulations for selected K-turn motifs from 23S ribosomal RNA, Kt-38 (located at the base of the A-site finger), Kt-42 (located at the base of the L7/L12 stalk in the factor-binding site) and Kt-58 (located in Domain III). On a nano-second timescale, K-turns sample isoenergetic conformational substates. The simulations reveal the presence of long-residency sites for water, one of which is located close to the sharp turn of the phosphodiester backbones and, when occupied, mediates minor-groove interactions between the st (en)
- Molecular dynamics (MD) simulations of Kink-turn (K-turn) RNA motifs reveal hinge-like motions on the nano-second (ns) timescale. K-turn motifs are asymmetric internal loops found at conserved positions in the 16S and 23S ribosomal RNAs, and characterized by sharp bends in both phosphodiester backbones producing V-shaped structures. The bend is stabilized by non-Watson-Crick basepairs involving the minor (shallow) grooves of the helices. We have carried out a set of explicit-solvent MD simulations for selected K-turn motifs from 23S ribosomal RNA, Kt-38 (located at the base of the A-site finger), Kt-42 (located at the base of the L7/L12 stalk in the factor-binding site) and Kt-58 (located in Domain III). On a nano-second timescale, K-turns sample isoenergetic conformational substates. The simulations reveal the presence of long-residency sites for water, one of which is located close to the sharp turn of the phosphodiester backbones and, when occupied, mediates minor-groove interactions between the st (cs)
|
Title
| - Hinge-like motions in RNA kink-turn motifs
- Hinge-like motions in RNA kink-turn motifs (en)
- Pantove pohyby RNA Kink-turn motivov (cs)
|
skos:prefLabel
| - Hinge-like motions in RNA kink-turn motifs
- Hinge-like motions in RNA kink-turn motifs (en)
- Pantove pohyby RNA Kink-turn motivov (cs)
|
skos:notation
| - RIV/00216224:14310/04:00010307!RIV08-MSM-14310___
|
http://linked.open.../vavai/riv/strany
| |
http://linked.open...avai/riv/aktivita
| |
http://linked.open...avai/riv/aktivity
| |
http://linked.open...vai/riv/dodaniDat
| |
http://linked.open...aciTvurceVysledku
| |
http://linked.open.../riv/druhVysledku
| |
http://linked.open...iv/duvernostUdaju
| |
http://linked.open...titaPredkladatele
| |
http://linked.open...dnocenehoVysledku
| |
http://linked.open...ai/riv/idVysledku
| - RIV/00216224:14310/04:00010307
|
http://linked.open...riv/jazykVysledku
| |
http://linked.open.../riv/klicovaSlova
| |
http://linked.open.../riv/klicoveSlovo
| |
http://linked.open...ontrolniKodProRIV
| |
http://linked.open...v/mistoKonaniAkce
| |
http://linked.open...i/riv/mistoVydani
| |
http://linked.open...i/riv/nazevZdroje
| - Modelling and Design of Molecular Materials, Program-Book of Abstract
|
http://linked.open...in/vavai/riv/obor
| |
http://linked.open...ichTvurcuVysledku
| |
http://linked.open...cetTvurcuVysledku
| |
http://linked.open...vavai/riv/projekt
| |
http://linked.open...UplatneniVysledku
| |
http://linked.open...iv/tvurceVysledku
| - Koča, Jaroslav
- Rázga, Filip
- Šponer, Jiří
- Leontis, Neocles B.
|
http://linked.open...vavai/riv/typAkce
| |
http://linked.open.../riv/zahajeniAkce
| |
number of pages
| |
http://purl.org/ne...btex#hasPublisher
| |
http://localhost/t...ganizacniJednotka
| |