About: A determination of submicromolar concentrations of glycine in periaquecuctal gray matter microdialyzates using capillary zone electrophoresis with contactless conductivity detection

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About: A determination of submicromolar concentrations of glycine in periaquecuctal gray matter microdialyzates using capillary zone electrophoresis with contactless conductivity detection Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Capillary electrophoresis (CE) with contactless conductivity detection (C4D) has been used to determine the glycine neurotransmitter in periaqueductal gray matter (PAG) of rats. The limit of detection for glycine has been decreased to a value of 0.2 ?M by adding 75% v/v of acetonitrile to the samples and increasing the sample zone introduced to a value of 20% of the overall capillary length. The repeatabilities of the analyte migration times and the zone areas amount to 2.1 and 2.7%, respectively. The optimized CE/C4D method makes it possible to determine micromolar concentrations of glycine in PAG microdialyzates without the necessity of sample derivatization. It follows from a pharmacological study that a local inflammation initiated by an application of carrageenan increased the glycine concentration in the rat PAG seven times, compared to a control. The glycine level in PAG can be decreased and the pain suppressed by administering paracetamol. Capillary electrophoresis (CE) with contactless conductivity detection (C4D) has been used to determine the glycine neurotransmitter in periaqueductal gray matter (PAG) of rats. The limit of detection for glycine has been decreased to a value of 0.2 ?M by adding 75% v/v of acetonitrile to the samples and increasing the sample zone introduced to a value of 20% of the overall capillary length. The repeatabilities of the analyte migration times and the zone areas amount to 2.1 and 2.7%, respectively. The optimized CE/C4D method makes it possible to determine micromolar concentrations of glycine in PAG microdialyzates without the necessity of sample derivatization. It follows from a pharmacological study that a local inflammation initiated by an application of carrageenan increased the glycine concentration in the rat PAG seven times, compared to a control. The glycine level in PAG can be decreased and the pain suppressed by administering paracetamol. (en)
Title	A determination of submicromolar concentrations of glycine in periaquecuctal gray matter microdialyzates using capillary zone electrophoresis with contactless conductivity detection A determination of submicromolar concentrations of glycine in periaquecuctal gray matter microdialyzates using capillary zone electrophoresis with contactless conductivity detection (en)
skos:prefLabel	A determination of submicromolar concentrations of glycine in periaquecuctal gray matter microdialyzates using capillary zone electrophoresis with contactless conductivity detection A determination of submicromolar concentrations of glycine in periaquecuctal gray matter microdialyzates using capillary zone electrophoresis with contactless conductivity detection (en)
skos:notation	RIV/00216208:11310/09:10001398!RIV10-GA0-11310___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA203/07/0896), Z(MSM0021620814), Z(MSM0021620816)
http://linked.open...iv/cisloPeriodika	19
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Štulík, Karel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	301239
http://linked.open...ai/riv/idVysledku	RIV/00216208:11310/09:10001398
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Amino acids; Contactless conductivity detection; Neurotransmitters (en)
http://linked.open.../riv/klicoveSlovo	Amino acids Contactless conductivity detection Neurotransmitters
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[58B228D3AADA]
http://linked.open...i/riv/nazevZdroje	Electrophoresis
http://linked.open...in/vavai/riv/obor	CB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Fast screening of biologically active low-molecular weight compounds in biological materials by microfluidic techniques
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	30
http://linked.open...iv/tvurceVysledku	Samcová, Eva Tůma, Petr Štulík, Karel Soukupová, Marie
http://linked.open...n/vavai/riv/zamer	Prevention, diagnostics and therapy of diabetes mellitus, metabolic and endocrine damage of organism Název: Patofyziologie neuropsychiatrických onemocnění a její klinické aplikace
issn	0173-0835
number of pages	6 (xsd:int)
http://localhost/t...ganizacniJednotka	11310

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