About: Cytotoxicity decreasing effect and antimycobacterial activity of chitosan conjugated with antituberculotic drugs

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About: Cytotoxicity decreasing effect and antimycobacterial activity of chitosan conjugated with antituberculotic drugs Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://www.sciencedirect.com/science/article/pii/S0144861710008660
Description	Water-soluble chitosan conjugates were prepared by connection with isoniazid, pyrazinamide and ethionamide across the O-carboxymethyl and N-succinyl bridge followed by phosphorylation. Their structures were characterized by FTIR and (1)H NMR spectroscopy. Degree of drug substitution and molecular weight of prepared compounds have been investigated. Antimycobacterial activity was determined against Mycobacterium tuberculosis and three non-tuberculosis strains. Water-soluble chitosan conjugates were prepared by connection with isoniazid, pyrazinamide and ethionamide across the O-carboxymethyl and N-succinyl bridge followed by phosphorylation. Their structures were characterized by FTIR and (1)H NMR spectroscopy. Degree of drug substitution and molecular weight of prepared compounds have been investigated. Antimycobacterial activity was determined against Mycobacterium tuberculosis and three non-tuberculosis strains. (en)
Title	Cytotoxicity decreasing effect and antimycobacterial activity of chitosan conjugated with antituberculotic drugs Cytotoxicity decreasing effect and antimycobacterial activity of chitosan conjugated with antituberculotic drugs (en)
skos:prefLabel	Cytotoxicity decreasing effect and antimycobacterial activity of chitosan conjugated with antituberculotic drugs Cytotoxicity decreasing effect and antimycobacterial activity of chitosan conjugated with antituberculotic drugs (en)
skos:notation	RIV/00216208:11160/11:10099482!RIV12-MZ0-11160___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(NS10367), S, Z(MSM0021620822)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Mandíková, Jana Trejtnar, František Vinšová, Jarmila Vavříková, Eva
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Univerzita Karlova v Praze / Farmaceutická fakulta v Hradci Králové
http://linked.open...dnocenehoVysledku	192644
http://linked.open...ai/riv/idVysledku	RIV/00216208:11160/11:10099482
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cytotoxicity; In vitro antimycobacterial activity; Ethionamide; Pyrazinamide; Isoniazid; Chitosan (en)
http://linked.open.../riv/klicoveSlovo	Cytotoxicity Ethionamide In vitro antimycobacterial activity Isoniazid Pyrazinamide Chitosan
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[BD4E36E49CBE]
http://linked.open...i/riv/nazevZdroje	Carbohydrate Polymers
http://linked.open...in/vavai/riv/obor	FR
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	Evaluation and development of new perspective antimycobacterial drugs and prodrugs active against multidrug resistant strains
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	83
http://linked.open...iv/tvurceVysledku	Vavříková, Eva Vinšová, Jarmila Bősze, Szilvia Horváti, Kata Mandíková, Jana Stolaříková, Jiřina Trejtnar, František
http://linked.open...ain/vavai/riv/wos	000286965400062
http://linked.open...n/vavai/riv/zamer	Research of new drug structures
issn	0144-8617
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.carbpol.2010.10.053
http://localhost/t...ganizacniJednotka	11160

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