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Description
| - It is widely believed that P-glycoprotein, together with other ATP efflux drug transporters, plays a crucial role in the host detoxication and protection against xenobiotic substances. On the other hand, the presence of these transporters in normal tissues may prevent pharmacotherapeutic agents from reaching their site of action, thus limiting their therapeutic potential. This review focuses on P-glycoprotein, its expression, localization, and function in nontumor tissues and the pharmacological consequences hereof. Special attention is paid to its role in pharmacokinetics of the small intestine, brain, kidney, liver and placenta.
- It is widely believed that P-glycoprotein, together with other ATP efflux drug transporters, plays a crucial role in the host detoxication and protection against xenobiotic substances. On the other hand, the presence of these transporters in normal tissues may prevent pharmacotherapeutic agents from reaching their site of action, thus limiting their therapeutic potential. This review focuses on P-glycoprotein, its expression, localization, and function in nontumor tissues and the pharmacological consequences hereof. Special attention is paid to its role in pharmacokinetics of the small intestine, brain, kidney, liver and placenta. (en)
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Title
| - Expression and function of P-glycoprotein in normal tissues: Effect on pharmacokinetics
- Expression and function of P-glycoprotein in normal tissues: Effect on pharmacokinetics (en)
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skos:prefLabel
| - Expression and function of P-glycoprotein in normal tissues: Effect on pharmacokinetics
- Expression and function of P-glycoprotein in normal tissues: Effect on pharmacokinetics (en)
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skos:notation
| - RIV/00216208:11160/10:00300602!RIV11-MSM-11160___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/00216208:11160/10:00300602
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - P-glycoprotein; expression; function; localization; normal tissues; pharmacokinetics; drug absorption; drug distribution; drug excretion (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Methods in Molecular Biology
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Mičuda, Stanislav
- Pávek, Petr
- Čečková, Martina
- Štaud, František
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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