About: Dendritic cell based cancer immunotherapy of ovarian cancer Phase I/II clinical trial     Goto   Sponge   NotDistinct   Permalink

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Description
  • We developed a dendritic cell-based vaccine for cancer immunotherapy. In this project, we plan to run a Phase I/II clinical trial in patients in the stage III-IV of ovarian cancer according the FIGO (International Federation of Gynecology and Obstetrics) classification. Primary endpoint will be the evaluation of vaccine safety. We will also evaluate the capacity to induce tumor specific immune response and objective clinical responses. This proposal is in accordance with the priority in the oncology section of the Ministry of Health program:Targeting of tumors by the modulation of the immune system. We expect to develop a novel treatment modality that would be incorporated into current protocols and that would improve the prognosis of patients with ovarian cancer. (en)
  • Na Ústavu imunologie byla vyvinuta individuální vakcína na bázi dendritických buněk schopná specificky aktivovat protinádorové imunitní mechanismy. Cílem projektu je klinická studie u pacientek s karcinomem ovaria ve stádiu III-IV dle FIGO (International Federation of Gynecology and Obstetrics) klasifikace. Bude vyhodnocena bezpečnost aplikace vakcín, schopnost indukce protinádorové imunitní reakce a klinická odpověď. Projekt odpovídá prioritám výzkumu MZČR v oblasti ovlivnění rozvoje nádorových onemocnění manipulací imunitního systému.
Title
  • Dendritic cell based cancer immunotherapy of ovarian cancer Phase I/II clinical trial (en)
  • Fáze I/II klinické studie imunoterapie ovariálního karcinomu pomocí vakcinace dendritickými buňkami
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  • NT12402
http://linked.open...avai/cep/aktivita
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  • dendritic cells; immunotherapy; ovaria cancer; clinical trial phase I-II (en)
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  • dendritic cells
  • immunotherapy
  • ovaria cancer
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