About: Significance of WT1 gene expression for prognosis and residual disease monitoring in childhood acute leukeamias.     Goto   Sponge   NotDistinct   Permalink

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Description
  • Proposed study will test prospectively the prognostic significance of WT1 expression at presentation and during therapy of paediatric acute myeloid leukemia. Quantitaion of WT1 transcript levels by real-time quantitative reverse-transcription PCR will be compared to flow cytometry detection of minimal residual disease. (en)
  • Navrhovaná studie bude prospektivně testovat prognostický význam exprese WT1 při diagnóze a v průběhu léčby akutní myeloidní leukemie. Porovnáme hladiny exprese WT1 kvantifikované pomocí %22real-timeů reversně transkriptásové PCR s detekcí residuální nemoci pomicí průtokové cytometrie.
Title
  • Significance of WT1 gene expression for prognosis and residual disease monitoring in childhood acute leukeamias. (en)
  • Význam genu WT1 pro prognosu a sledování residuální nemoci u dětských leukemií
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  • NE7439
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  • WT1;childhood AML;minimal residual disease;RQ-PCR;flow cytometry;stem cell transplantation (en)
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  • GenWT1 je hyperexprimován v oblastech části dětských pacientů s hematolog.malignitami,tato hyperexprese však není jednoznačným markerem nádorového procesu.Využití v detekci reziduální nemoci je možné zřejmě u pacientů s akut.myel.leukémií. (cs)
  • WT1gene is hyperexpressed in blasts of a proportion of childhood patients with haematological malignancies but it si not an unequivocal marker of malignant process.It can be used form residual disease detection in patients with acute myeloid leukaemia. (en)
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  • flow cytometry
  • WT1
  • minimal residual disease
  • RQ-PCR
  • childhood AML
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