About: Steroids and thyreopathies     Goto   Sponge   NotDistinct   Permalink

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Description
  • Steroids with newly revealed immunoprotective and antiglucocorticoid activity will be investigated in groups of most frequent thyreopathies as Hashimoto ´s thyroiditis, Graves-Basedow diseases and in subclinical hypo- or hyperthyreosis. Besides dehydroepiandrosterone and 7-hydroxylated metabolites, their precursors and sulphates and major phytoestrogens will be followed with regard to their possible influence of thyroid function. (en)
  • Steroidy s nově objevenou imunoprotektivní a antiglukokortikoidní účinností budou vyšetřeny u souborů nejčastějších tyreopatií jako jsou Hashimotova tyroitida, Gravesova-Basedowova choroba a u subklinické hypo- resp. hypertyreosy. Vedle dehydroepiandrosteronu a jeho 7 - hydroxylovaných metabolitů, jejich prekursorů a sulfátů budou sledovány i vybrané fytoestrogeny vzhledem k jejich možnému ovlivnění tyroidální funkce.
Title
  • Steroids and thyreopathies (en)
  • Steroidy a tyreopatie.
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  • NB6313
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  • steroids;thyreopathies;7-hydroxysteroids;autoimmunity;antiglucocorticoids;DHEA/S;phytoestrogens (en)
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  • Výsledky grantu obohacují dosavadní poznání o nová fakta, ale vedle toho mají i perspektivní dopad klinický. Clinical chemistry and laboratory medicine (IF 1,595). (cs)
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  • autoimmunity
  • steroids
  • 7-hydroxysteroids
  • DHEA/S
  • antiglucocorticoids
  • thyreopathies
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