About: Modulation of TNF-alpha and IL-1 activity as the treatment option during endotoxin induced organ injury.

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About: Modulation of TNF-alpha and IL-1 activity as the treatment option during endotoxin induced organ injury. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Projekt, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/domain/vavai/Projekt
Description	Cílem předkládaného projektu je zhodnocení potenciálu kortikosteroidů a blokátorů IL-1 receptorů v léčbě endotoxinem navozeného postižení jater, plic a ledvin za použití validovaného in vivo potkaního modelu a molekulárně-biologických metod. (cs) The present project is aimed at physiologically based evaluation of pharmacokinetics and pharmacodynamics of compounds with special attention paid to transport systems in the liver and kidney. These transport systems are highly altered during endotoxemia, a common clinical problem, produced by lipopolysaccharides released from gramnegative bacteria. Because the whole cascade of events is initiated by proinflammatory stimuli, appropriate suppression of inflammation may reduce organ impairment. Therefore, the present extension of previous COST project aimed at finishing of started works to allow matching of in vivo anti-inflammatory potential of corticosteroids and IL-1-antagonists with the function and expression of basic excretory pathways in the liver and kidney during endotoxemia. Validated rat in vivo pathophysiological model of toxic liver and renal injury will be used to evaluate bile acid kinetics, expression of transport and regulatory molecules in respective tissue together with histological (en)
Title	Modulation of TNF-alpha and IL-1 activity as the treatment option during endotoxin induced organ injury. (en) Modulace aktivity TNF-alfa a IL-1 jako potenciální léčebná strategie endotoxinem navozeného orgánového poškození (cs)
http://linked.open...vai/cislo-smlouvy	http://linked.opendata.cz/resource/domain/vavai/cep/smlouva/1 682/2009-32
http://linked.open...lsi-vedlejsi-obor	http://linked.opendata.cz/resource/domain/vavai/cep/obor/FN
http://linked.open...avai/druh-souteze	http://linked.opendata.cz/resource/domain/vavai/cep/druh-souteze/VS
http://linked.open...domain/vavai/faze	http://linked.opendata.cz/resource/domain/vavai/cep/faze/37049619
http://linked.open...vavai/hlavni-obor	http://linked.opendata.cz/resource/domain/vavai/cep/obor/FR
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http://linked.open...vavai/id-aktivity	http://linked.opendata.cz/resource/domain/vavai/cep/aktivita/OC
http://linked.open.../vavai/id-souteze	http://linked.opendata.cz/resource/domain/vavai/cep/soutez/SMSM2009OC4
http://linked.open...n/vavai/kategorie	http://linked.opendata.cz/resource/domain/vavai/cep/kategorie/1
http://linked.open...vai/klicova-slova	endotoxemia; glucocorticoids; anakinra (en)
http://linked.open...avai/konec-reseni	2009-05-31 (xsd:date)
http://linked.open...nujicich-prijemcu	0 (xsd:integer)
http://linked.open...avai/poskytovatel	http://linked.opendata.cz/resource/domain/vavai/cep/poskytovatel/MSM
http://linked.open...avai/start-reseni	2009-04-01 (xsd:date)
http://linked.open...ai/statni-podpora	350 (xsd:integer)
http://linked.open...vavai/typProjektu	http://linked.opendata.cz/resource/domain/vavai/cep/typ/P
http://linked.open...ai/uznane-naklady	350 (xsd:integer)
http://linked.open...ai/pocet-prijemcu	1 (xsd:integer)
http://linked.open...cet-spoluprijemcu	0 (xsd:integer)
http://linked.open...ai/pocet-vysledku	2 (xsd:integer)
http://linked.open...ku-zverejnovanych	2 (xsd:integer)
is http://linked.open...ain/vavai/projekt of	http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2009/OC09072/orjk-11150 http://linked.opendata.cz/resource/domain/vavai/cep/ucast/2010/OC09072/orjk-11150

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