About: Suramin

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Suramin
rdfs:subClassOf	Angiogenesis Activator Inhibitor nodeID://b716383 nodeID://b716384 nodeID://b716385 nodeID://b716386 nodeID://b716387 nodeID://b716388
Has_Salt_Form	Suramin Sodium
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Suramin
UMLS_CUI	C0038880
CAS_Registry	145-63-1
Accepted_Therapeutic_Use_For	Trypanosomiasis; hormone-refractory prostate cancer
In_Clinical_Trial_For	Bladder cancer; Breast cancer; Non-small cell lung cancer; Renal cell cancer
FDA_UNII_Code	6032D45BEM
Contributing_Source	FDA
ALT_DEFINITION	A drug that is used to treat infections caused by parasites. It is also being studied in the treatment of cancer. It belongs to the families of drugs called antiprotozoals and anthelmintics.NCI-GLOSS
PDQ_Open_Trial_Search_ID	40052
PDQ_Closed_Trial_Search_ID	40052
Chemical_Formula	C51H40N6O23S6
Legacy_Concept_Name	Suramin
CHEBI_ID	CHEBI:45906
FULL_SYN	SURAMINPTFDA6032D45BEM suraminPTNCI-GLOSSCDR0000045271 SuraminPTNCI
DEFINITION	A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. (NCI04)NCI
code	C853
is someValuesFrom of	nodeID://b645406 nodeID://b645413 nodeID://b657283 nodeID://b667193 nodeID://b667703 nodeID://b674190 nodeID://b674191 nodeID://b674206 nodeID://b674209 nodeID://b676717 nodeID://b680756 nodeID://b686840 nodeID://b701499 nodeID://b702275 nodeID://b713334 nodeID://b716395
is Has_Free_Acid_Or_Base_Form of	Suramin Sodium

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