About: Liposome-Encapsulated Irinotecan Hydrochloride PEP02     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Liposome-Encapsulated Irinotecan Hydrochloride PEP02
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Liposome-Encapsulated Irinotecan Hydrochloride PEP02
NCI_META_CUI
  • CL388459
PDQ_Open_Trial_Search_ID
  • 632436
PDQ_Closed_Trial_Search_ID
  • 632436
Legacy_Concept_Name
  • Liposome-Encapsulated_Irinotecan_Hydrochloride_PEP02
FULL_SYN
  • Liposome-Encapsulated Irinotecan Hydrochloride PEP02PTNCI
  • PEP02CNNCI
DEFINITION
  • A liposomal formulation of the hydrochloride salt of the semisynthetic camptothecin analogue irinotecan with potential antineoplastic activity. During the S phase of the cell cycle, irinotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Liposome encapsulation of this agent promotes efficient drug delivery into the cytosol from the endosome compartment of the cell.NCI
code
  • C82676
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