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AttributesValues
rdf:type
rdfs:label
  • Loracarbef
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Loracarbef
UMLS_CUI
  • C0721422
CAS_Registry
  • 121961-22-6
FDA_UNII_Code
  • 3X11EVM5SU
Contributing_Source
  • FDA
Chemical_Formula
  • C16H16ClN3O4.H2O
Legacy_Concept_Name
  • Loracarbef
FULL_SYN
  • LorabidBRNCI
  • LORACARBEFPTFDA3X11EVM5SU
  • (6R, 7S)-7-[(R)-2-Amino-2-phenylacetamido]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, MonohydrateSNNCI
  • LoracarbefPTNCI
DEFINITION
  • A semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiotic derived from cephasporium. The bactericidal activity of loracarbef results from the inhibition of bacterial cell wall synthesis through interference with the cross-linking of peptidoglycan units. This results in a reduction of cell wall stability and causes cell lysis. Loracarbef is more active against a variety of gram-negative organisms but less active against gram-positive pathogens compared to first-generation agents.NCI
code
  • C47588
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