About: CYP2D6*8 Allele     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • CYP2D6*8 Allele
rdfs:subClassOf
OMIM_Number
  • 124030
GenBank_Accession_Number
  • NM_000106
Semantic_Type
  • Gene or Genome
Preferred_Name
  • CYP2D6*8 Allele
PubMedID_Primary_Reference
  • 8530011
UMLS_CUI
  • C1707230
Legacy_Concept_Name
  • CYP2D6_8_Allele
FULL_SYN
  • Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*8 AlleleSYNCI
  • CYP2D6*8 AllelePTNCI
  • CYP2D6, g.1758G>TSYNCI
  • CYP2D6GSYNCI
  • CYP2D6*8SYNCI
Gene_Encodes_Product
  • Cytochrome P450 2D6
DEFINITION
  • Human CYP2D6*8 allele is located in the vicinity of 22q13.1 and is approximately 4 kb in length. This allele, a variant form of the CYP2D6 wild-type allele, encodes cytochrome P450 2D6*8 protein. The CYP2D6*8 allele exhibits a clinically-relevant SNP (g.1758G>T) in exon 3 that generates a stop codon. This alteration yields a truncated cytochrome P450 2D6*8 protein that is enzymatically inactive.NCI
DesignNote
  • Ethnicity Association: Caucasian
code
  • C45623
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