About: Dactinomycin

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Attributes	Values
rdf:type	Class
rdfs:label	Dactinomycin
rdfs:subClassOf	Actinomycin Antineoplastic Antibiotic
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Amino Acid, Peptide, or Protein Antibiotic
Preferred_Name	Dactinomycin
NSC_Code	3053
UMLS_CUI	C0010934
CAS_Registry	50-76-0
Accepted_Therapeutic_Use_For	Wilms' tumor; rhabdomyosarcoma; Ewing's sarcoma; testicular cancer; gestational trophoblastic neoplasia; choriocarcinoma; melanoma; neuroblastoma; retinoblastoma; uterine sarcomas; Kaposi's sarcoma; sarcoma botryoides; soft tissue sarcoma.
In_Clinical_Trial_For	unresectable regional melanoma; unresectable soft tissue sarcoma; childhood fibrosarcoma; leukemia; lymphoma; relapsed or refractory clear cell sarcoma of the kidney; malignant mesenchymal tumors Gestational trophoblastic neoplasia; hydatidiform mole; uterine choriocarcinoma; Ewing's sarcoma; rhabdomyosarcoma; Wilm's Tumor
FDA_UNII_Code	1CC1JFE158
Contributing_Source	FDA
ALT_DEFINITION	An anticancer drug that is a type of antitumor antibiotic.NCI-GLOSS
PDQ_Open_Trial_Search_ID	39675
PDQ_Closed_Trial_Search_ID	39675
Chemical_Formula	C62H86N12O16
Legacy_Concept_Name	Dactinomycin
CHEBI_ID	CHEBI:27666
FULL_SYN	DACTINOMYCINPTFDA1CC1JFE158 ACTINOMYCIN DSYDTPNSC0003053 DactinomycinPTNCI 2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3SNNCI Actinomycin DSYNCI DactinomycineSYNCI Actinomycin-[thr-val-pro-sar-meval]SYNCI Actinomycin C1SYNCI Actinomycin I1SYNCI Actinomycin IVSYNCI MeractinomycinSYNCI Actinomycin IVSYDTPNSC0003053 dactinomycinPTNCI-GLOSSCDR0000045237 Actinomycin X 1SYNCI Lyovac CosmegenFBNCI MeractinomycinSYDTPNSC0003053 DACTABNCI Actinomycin X 1SYDTPNSC0003053 DactinomycinPTDCP00417 Actinomycin A IVSYNCI Lyovac cosmegenSYDTPNSC0003053 CosmegenSYDTPNSC0003053 CosmegenBRNCI
DEFINITION	A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus. Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04)NCI
code	C412
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