About: Nitric Oxide Signaling Pathway

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About: Nitric Oxide Signaling Pathway Goto Sponge NotDistinct Permalink

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Attributes	Values
rdf:type	Class
rdfs:label	Nitric Oxide Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	Nitric Oxide Signaling Pathway
UMLS_CUI	C1518333
BioCarta_ID	h_nos1Pathway
ALT_DEFINITION	Glutamatergic-mediated nitric oxide (NO) production occurs via the N-methyl-D-aspartic acid (NMDA) postsynaptic density protein 95 (PSD95)-neuronal nitric oxide synthase (NOS1) ternary complex. The increased intracellular Ca2+ stimulates the interaction of nNOS and calmodulin (CaM) and the translocation of nNOS from the plasma membrane to the cytoplasm. The dephosphorylation of nNOS by Calcineurin catalyzes the conversion of arginine to citrulline and nitric oxide (NO), which turns on guanylate cyclase and the various cGMP regulated signaling pathways.BIOCARTA
Legacy_Concept_Name	Nitric_Oxide_Signaling_Pathway
FULL_SYN	Nitric Oxide Signaling PathwayPTBIOCARTA Nitric Oxide Signaling PathwayPTNCI
code	C39169
is someValuesFrom of	nodeID://b656376 nodeID://b665307 nodeID://b674536 nodeID://b675677 nodeID://b675688 nodeID://b677113 nodeID://b677132 nodeID://b695571 nodeID://b696868 nodeID://b700333 nodeID://b700524 nodeID://b700575 nodeID://b700622 nodeID://b700666 nodeID://b700724 nodeID://b704030 nodeID://b704939 nodeID://b704992 nodeID://b705041 nodeID://b705198 nodeID://b725743
is Has_Target of	ISOSORBIDE

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