About: HIV-I Nef in Apoptosis Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	HIV-I Nef in Apoptosis Pathway
rdfs:subClassOf	Apoptosis Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	HIV-I Nef in Apoptosis Pathway
UMLS_CUI	C1512300
BioCarta_ID	h_HivnefPathway
ALT_DEFINITION	HIV infection leads to drastic declines in CD4 T helper cells, in part through apoptosis of uninfected cells. Apoptosis of uninfected cells may be induced through the expression of Fas ligand on the surface of HIV-infected cells, stimulating the Fas-dependent apoptotic pathway in cells that come in contact with infected cells. The NEF protein expressed by HIV may play a role in the inducing the expression of Fas-ligand by infected cells. If this is the case, then a question that arises is how infected cells themselves escape Fas-mediated apoptosis. The NEF protein appears to play a role in this process as well. NEF interacts with the ASK1 kinase (apoptosis signal-regulating kinase) involved in apoptotic signaling by TNF and Fas-ligand. Interaction of NEF with ASK1 prevents phosphorylation of downstream MAP kinases and JNK kinases involved in apoptotic signaling.BIOCARTA
Legacy_Concept_Name	HIV-I_Nef_in_Apoptosis_Pathway
FULL_SYN	HIV-I Nef: negative effector of Fas and TNFPTBIOCARTA HIV-I Nef in Apoptosis PathwayPTNCI
code	C39106
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