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AttributesValues
rdf:type
rdfs:label
  • Abatacept
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Abatacept
NSC_Code
  • 710084
UMLS_CUI
  • C1619966
CAS_Registry
  • 332348-12-6
FDA_UNII_Code
  • 7D0YB67S97
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 660119
PDQ_Closed_Trial_Search_ID
  • 660119
Legacy_Concept_Name
  • CTLA4-Ig
FULL_SYN
  • cytotoxic T lymphocyte-associated antigen-4SYNCI
  • RG2077CNNCI
  • ABATACEPTPTFDA7D0YB67S97
  • OrenciaBRNCI
  • CTLA4-IgSYNCI
  • AbataceptPTNCI
  • BMS-188667CNNCI
  • CTL A4-Ig B7 InhibitorSYNCI
DEFINITION
  • A soluble fusion protein consisting of the extracellular domain of human cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) linked to a modified Fc (hinge, CH2, and CH3 domains) portion of human immunoglobulin G1 (IgG1) with immunosuppressive activity. Abatacept binds CD80 and CD86 on antigen presenting cells (APCs), blocking interaction with CD28 on T lymphocytes, which initiates a co-stimulatory signal required for full activation of T lymphocytes.NCI
code
  • C28898
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