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AttributesValues
rdf:type
rdfs:label
  • Mafosfamide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
  • Organophosphorus Compound
Preferred_Name
  • Mafosfamide
NSC_Code
  • 345842
UMLS_CUI
  • C0065506
CAS_Registry
  • 88859-04-5
In_Clinical_Trial_For
  • Brain tumors, infant; meningeal neoplasms
FDA_UNII_Code
  • 5970HH9923
Contributing_Source
  • FDA
ALT_DEFINITION
  • A form of cyclophosphamide that can be administered as an intrathecal infusion. Mafosfamide is being studied as an anticancer drug. It belongs to the family of drugs called alkylating agents.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 41254
PDQ_Closed_Trial_Search_ID
  • 41254
Chemical_Formula
  • C9H19Cl2N2O5PS2
Legacy_Concept_Name
  • Mafosfamide
FULL_SYN
  • MafosfamideSYDTPNSC0345842
  • MafosfamidePTNCI
  • mafosfamidePTNCI-GLOSSCDR0000045350
  • MAFOSFAMIDEPTFDA5970HH9923
DEFINITION
  • A synthetic oxazaphosphorine derivative with antineoplastic properties. Mafosfamide alkylates DNA, forming DNA cross-links and inhibiting DNA synthesis. Although closely related to cyclophosphamide, mafosfamide, unlike cyclophosphamide, does not require hepatic activation to generate its active metabolite 4-hydroxy-cyclophosphamide; accordingly, mafosfamide is potentially useful in the intrathecal treatment of neoplastic meningitis. (NCI04)NCI
code
  • C1150
is someValuesFrom of
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