About: PBN Derivative OKN-007     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • PBN Derivative OKN-007
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • PBN Derivative OKN-007
UMLS_CUI
  • C2974636
CAS_Registry
  • 168021-79-2
PDQ_Open_Trial_Search_ID
  • 739669
PDQ_Closed_Trial_Search_ID
  • 739669
FULL_SYN
  • NXY-059CNNCI
  • 2,4-Disulfophenyl-tert-butylnitroneSNNCI
  • OKN007CNNCI
  • 2,4-Disulfonyl PBNSYNCI
  • OKN-007CNNCI
  • PBN Derivative OKN-007PTNCI
DEFINITION
  • A disulfonyl derivative of phenyl-tert-butyl nitrone (PBN), with potential anti-glioma activity. Although the exact mechanism(s) of action of OKN007 are still largely unknown, this agent appears to inhibit cancer cell proliferation and migration. This agent appears to inhibit the activity of sulfatase 2 (SULF2), a highly specific endoglucosamine-6-sulfatase that is overexpressed in the extracellular matrix of cancer cells and catalyzes the removal of sulfate from the 6-O-sulfate esters of heparin. In addition, OKN007 may induce changes in tumor metabolism and scavenge free radicals.NCI
code
  • C102983
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