About: Diethylstilbestrol

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A synthetic nonsteroidal estrogen used in the treatment of menopausal and postmenopausal disorders. It was also used formerly as a growth promoter in animals. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), diethylstilbestrol has been listed as a known carcinogen. (Merck, 11th ed) (en)
http://linked.open...generalReferences	# : Leuprolide versus diethylstilbestrol for metastatic prostate cancer. The Leuprolide Study Group. N Engl J Med. 1984 Nov 15;311(20):1281-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/6436700 # DIECKMANN WJ, DAVIS ME, RYNKIEWICZ LM, POTTINGER RE: Does the administration of diethylstilbestrol during pregnancy have therapeutic value? Am J Obstet Gynecol. 1953 Nov;66(5):1062-81. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/13104505 # Ingle JN, Ahmann DL, Green SJ, Edmonson JH, Bisel HF, Kvols LK, Nichols WC, Creagan ET, Hahn RG, Rubin J, Frytak S: Randomized clinical trial of diethylstilbestrol versus tamoxifen in postmenopausal women with advanced breast cancer. N Engl J Med. 1981 Jan 1;304(1):16-21. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7001242 # Kuchera LK: Postcoital contraception with diethylstilbestrol. JAMA. 1971 Oct 25;218(4):562-3. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/5171004 # Herbst AL, Ulfelder H, Poskanzer DC: Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med. 1971 Apr 15;284(15):878-81. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/5549830 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	Used in the treatment of prostate cancer. Previously used in the prevention of miscarriage or premature delivery in pregnant women prone to miscarriage or premature delivery. (en)
http://linked.open...bank/manufacturer	Bristol myers squibb Bayer Healthcare Carolina Medical Products Co. Bayer pharmaceuticals corp
sameAs	Diethylstilbestrol
Title	Diethylstilbestrol (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00255/identifier/chebi/4531 http://linked.opendata.cz/resource/drugbank/drug/DB00255/identifier/chemspider/2946 http://linked.opendata.cz/resource/drugbank/drug/DB00255/identifier/drugbank/DB00255 http://linked.opendata.cz/resource/drugbank/drug/DB00255/identifier/kegg-compound/C07620 http://linked.opendata.cz/resource/drugbank/drug/DB00255/identifier/kegg-drug/D00577 http://linked.opendata.cz/resource/drugbank/drug/DB00255/identifier/pdb/DES http://linked.opendata.cz/resource/drugbank/drug/DB00255/identifier/pharmgkb/PA449307 http://linked.opendata.cz/resource/drugbank/drug/DB00255/identifier/pubchem-compound/448537 http://linked.opendata.cz/resource/drugbank/drug/DB00255/identifier/pubchem-substance/46507453 http://linked.opendata.cz/resource/drugbank/drug/DB00255/identifier/wikipedia/Diethylstilbestrol
http://linked.open...mechanismOfAction	Estrogens diffuse into their target cells and interact with a protein receptor, the estrogen receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. The effect of Estrogen binding their receptors causes downstream increases the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH). (en)
http://linked.open...drugbank/packager	Medisca Inc.
http://linked.open.../drugbank/synonym	Diethylstilbestrol (en) Distilbene (en) Stilboestrol (en) DES (en) Dietilestilbestrol (en) trans-Diethylstilbesterol (en) trans-Diethylstilbestrol (en) trans-Diethylstilboesterol (en) (E)-3,4-bis(4-hydroxyphenyl)-3-hexene (en) (e)-4,4'-(1,2-Diethyl-1,2-ethenediyl)bisphenol (en) 4,4'-Dihydroxy-alpha,beta-diethylstilbene (en) 4,4'-dihydroxy-α,β-diethylstilbene (en) Diethylstilbestrolum (en) alpha,Alpha'-diethyl-(e)-4,4'-stilbenediol (en) trans-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol (en) α,α'-diethyl-(E)-4,4'-stilbenediol (en)
http://linked.open...drugbank/toxicity	Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/68-16-04
http://linked.open...ynthesisReference	Adler, E.,Gie, G.J. and von Euler, H.; US. Patent 2,421,401; June 3, 1947; assigned to Hoffmann-La Roche, Inc. (en)
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http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B4097-363D-11E5-9242-09173F13E4C5
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http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4093-363D-11E5-9242-09173F13E4C5
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http://linked.open...l/drug/hasATCCode	Diethylstilbestrol Diethylstilbestrol Diethylstilbestrol
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	56-53-1 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Diethylstilbestrol powder
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B40A3-363D-11E5-9242-09173F13E4C5
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http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B409F-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B40A0-363D-11E5-9242-09173F13E4C5

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