About: Reteplase

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Human tissue plasminogen activator, purified, glycosylated, 355 residues purified from CHO cells. Retavase is considered a "third-generation" thrombolytic agent, genetically engineered to retain and delete certain portions of human tPA. Retavase is a deletion mutein of human tPA formed by deleting various amino acids present in endogenous human tPA. Retavase contains 355 of the 527 amino acids of native human tPA (amino acids 1-3 and 176-527), and retains the activity-related kringle-2 and serine protease domains of human tPA. Three domains are deleted from retavase - kringle-1, finger, and epidermal growth factor (EGF). (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B3F5E-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For lysis of acute pulmonary emboli, intracoronary emboli and management of myocardial infarction (en)
sameAs	Reteplase
Title	Reteplase (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00015/identifier/drugbank/DB00015 http://linked.opendata.cz/resource/drugbank/drug/DB00015/identifier/genbank/L00153 http://linked.opendata.cz/resource/drugbank/drug/DB00015/identifier/national-drug-code-directory/24477-041-02 http://linked.opendata.cz/resource/drugbank/drug/DB00015/identifier/uniprotkb/P00750 http://linked.opendata.cz/resource/drugbank/drug/DB00015/identifier/pharmgkb/PA164743728 http://linked.opendata.cz/resource/drugbank/drug/DB00015/identifier/wikipedia/Reteplase
http://linked.open...mechanismOfAction	Reteplase binds to fibrin rich clots via the fibronectin finger-like domain and the Kringle 2 domain. The protease domain then cleaves the Arg/Val bond in plasminogen to form plasmin. Plasmin in turn degrades the fibrin matrix of the thrombus, thereby exerting its thrombolytic action. (en)
http://linked.open...drugbank/packager	EKR Therapeutics Inc. Hospira Inc. PDL BioPharma Inc.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/2107476
http://linked.open.../drugbank/synonym	Tissue-type plasminogen activator precursor (en) t- PA (en) t-plasminogen activator (en) tPA (en)
foaf:page	http://www.drugs.com/cdi/reteplase.html http://www.rxlist.com/cgi/generic2/reteplase.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B3F63-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B3F62-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Reteplase
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	133652-38-7 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Retavase vial half-kit
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B3F60-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B3F61-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B3F5F-363D-11E5-9242-09173F13E4C5

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