About: Anti-prolactin Receptor Antibody LFA102     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Anti-prolactin Receptor Antibody LFA102
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Anti-prolactin Receptor Antibody LFA102
NCI_META_CUI
  • CL429368
PDQ_Open_Trial_Search_ID
  • 699731
PDQ_Closed_Trial_Search_ID
  • 699731
FULL_SYN
  • LFA102CNNCI
  • Anti-prolactin Receptor Antibody LFA102PTNCI
DEFINITION
  • A neutralizing antibody against the prolactin receptor (PRLR) with potential antineoplastic activity. Upon administration, anti-prolactin receptor antibody LFA102 binds to PRLR and prevents the binding of the peptide hormone prolactin (PRL) to its receptor. This binding induces an antibody-dependent cellular cytotoxicity (ADCC) and may eventually prevent tumor cell proliferation in PRLR-positive cancer cells. PRLR/PRL signaling pathway is frequently overexpressed in breast and prostate cancer.NCI
code
  • C96744
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