About: Hydroxyprogesterone Caproate

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Hydroxyprogesterone Caproate
rdfs:subClassOf	PROGESTINS
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Steroid
Preferred_Name	Hydroxyprogesterone Caproate
NSC_Code	17592
UMLS_CUI	C0044971
CAS_Registry	630-56-8
Accepted_Therapeutic_Use_For	Endometrial cancer; amenorrhea
FDA_UNII_Code	276F2O42F5
Contributing_Source	FDA
PDQ_Open_Trial_Search_ID	39803
PDQ_Closed_Trial_Search_ID	39803
Chemical_Formula	C27H40O4
Legacy_Concept_Name	Hydroxyprogesterone_Caproate
FULL_SYN	HYDROXYPROGESTERONE CAPROATEPTFDA276F2O42F5 17alpha-Hydroxyprogesterone CaproateSYNCI 17-[(1-Oxohexyl)oxy]pregn-4-ene-3,20-dionePTDCP01767 Hydroxyprogesterone caproateSYDTPNSC0017592 MakenaBRNCI Hydroxyprogesterone CaproatePTNCI DelalutinSYDTPNSC0017592 17-[(1-Oxohexyl)oxy]pregn-4-ene-3,20-dioneSNNCI DelalutinBRNCI
DEFINITION	A synthetic progestational agent similar to the endogenous progesterone used in hormone therapy or as a female contraceptive. Mimicking the action of progesterone, hydroxyprogesterone caporate binds to and activates nuclear progesterone receptors in the reproductive system and causes the ligand-receptor complex to be translocated to the nucleus where it binds to and promotes expression of target genes. Due to the negative feedback mechanism seen with progesterone, this agent also blocks luteinizing hormone (LH) release from the pituitary gland, thereby leading to an inhibition of ovulation and an alteration in the cervical mucus and endometrium. Furthermore, without stimulation of LH, estrogen release from the ovaries is stopped, hence impeding the growth of estrogen-sensitive tumor cells.NCI
code	C960
sameAs	HYDROXYPROGESTERONE CAPROATE HYDROXYPROGESTERONE CAPROATE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0074009
is sameAs of	HYDROXYPROGESTERONE CAPROATE HYDROXYPROGESTERONE CAPROATE HYDROXYPROGESTERONE CAPROATE HYDROXYPROGESTERONE CAPROATE

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