About: Gastric Acid Secretion Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Gastric Acid Secretion Pathway
rdfs:subClassOf	Homeostasis Regulation Pathway
Semantic_Type	Functional Concept
Preferred_Name	Gastric Acid Secretion Pathway
UMLS_CUI	C2984576
KEGG_ID	hsa04971
ALT_DEFINITION	Gastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections. The principal stimulants of acid secretion at the level of the parietal cell are histamine (paracrine), gastrin (hormonal), and acetylcholine (ACh; neurocrine). Stimulation of acid secretion typically involves an initial elevation of intracellular calcium and cAMP, followed by activation of protein kinase cascades, which trigger the translocation of the proton pump, H+, K+-ATPase, from cytoplasmic tubulovesicles to the apical plasma membrane and H+ secretion into the stomach lumen.KEGG
FULL_SYN	Gastric acid secretionPTKEGG Gastric Acid Secretion PathwayPTNCI
code	C91811
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