About: Bacterial Invasion of Epithelial Cell Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Bacterial Invasion of Epithelial Cell Pathway
rdfs:subClassOf	Infectious Disease Pathway
Semantic_Type	Functional Concept
Preferred_Name	Bacterial Invasion of Epithelial Cell Pathway
UMLS_CUI	C2984569
KEGG_ID	hsa05100
ALT_DEFINITION	Many pathogenic bacteria can invade phagocytic and non-phagocytic cells, colonize them intracellularly, and then become disseminated to other cells. Invasive bacteria induce their own uptake by non-phagocytic host cells (e.g. epithelial cells) using two mechanisms referred to as zipper model and trigger model. Listeria, Staphylococcus, Streptococcus, and Yersinia are examples of bacteria that enter using the zipper model. These bacteria express proteins on their surfaces that interact with cellular receptors, initiating signaling cascades that result in close apposition of the cellular membrane around the entering bacteria. Shigella and Salmonella are the examples of bacteria entering cells using the trigger model. These bacteria use type III secretion systems to inject protein effectors that interact with the actin cytoskeleton.KEGG
FULL_SYN	Bacterial Invasion of Epithelial Cell PathwayPTNCI Bacterial invasion of epithelial cellsPTKEGG
code	C91804
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