About: RIG-I-Like Receptor Signaling Pathway

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About: RIG-I-Like Receptor Signaling Pathway Goto Sponge Distinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	RIG-I-Like Receptor Signaling Pathway
rdfs:subClassOf	Signaling Pathway
Semantic_Type	Functional Concept
Preferred_Name	RIG-I-Like Receptor Signaling Pathway
UMLS_CUI	C2984316
KEGG_ID	hsa04622
ALT_DEFINITION	Specific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular viral replication is recognized by a family of cytosolic RNA helicases termed RIG-I-like receptors (RLRs). The RLR proteins include RIG-I, MDA5, and LGP2 and are expressed in both immune and nonimmune cells. Upon recognition of viral nucleic acids, RLRs recruit specific intracellular adaptor proteins to initiate signaling pathways that lead to the synthesis of type I interferon and other inflammatory cytokines, which are important for eliminating viruses.KEGG
FULL_SYN	RIG-I-Like Receptor Signaling PathwayPTNCI RIG-I-like receptor signaling pathwayPTKEGG
code	C91507
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