About: Colorectal Cancer Pathway

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Attributes	Values
rdf:type	Class
rdfs:label	Colorectal Cancer Pathway
rdfs:subClassOf	Cancer Pathway
Semantic_Type	Functional Concept
Preferred_Name	Colorectal Cancer Pathway
UMLS_CUI	C2984278
KEGG_ID	hsa05210
ALT_DEFINITION	Classically, colorectal cancer (CRC) has been believed to develop from normal mucosa through the premalignant adenoma by the step-wise accumulation of mutations. All CRC display either microsatellite instability (MSI) or chromosome instability (CIN). MSI occurs in 15% of colon cancers and results from inactivation of the DNA mismatch repair (MMR) system by either MMR gene mutations or hypermethylation of the MLH1 promoter. MSI promotes tumorigenesis through generating mutations in target genes that possess coding microsatellite repeats, such as beta-catenin, TGFBR2 and BAX. CIN is found in the majority of colon cancers and leads to a different pattern of gene alterations that contribute to tumor formation. Genes involved in CIN are those coding for APC, K-ras, SMAD4 and p53.KEGG
FULL_SYN	CRC PathwaySYNCI Colorectal Cancer PathwayPTNCI Colorectal cancerPTKEGG
code	C91466
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