About: TPH Inhibitor LX1606     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • TPH Inhibitor LX1606
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • TPH Inhibitor LX1606
OLD_PARENT
  • Enzyme_Inhibitor
NCI_META_CUI
  • CL413594
Concept_Status
  • Retired_Concept
PDQ_Open_Trial_Search_ID
  • 662188
PDQ_Closed_Trial_Search_ID
  • 662188
FULL_SYN
  • LX1606CNNCI
  • Tryptophan Hydroxylase Inhibitor LX1606SYNCI
  • TPH Inhibitor LX1606PTNCI
DEFINITION
  • An orally bioavailable, small-molecule, tryptophan hydroxylase (TPH) inhibitor prodrug with potential antiserotonergic activity. Upon administration, TPH inhibitor LX1606 is converted to its active metabolite LP-778902, which binds to and blocks the activity of TPH. This may result in a reduction in peripheral serotonin (5-HT) production and improvement of serotonin-mediated gastrointestinal effects such as severe diarrhea. TPH, the rate-limiting enzyme in serotonin biosynthesis, is overexpressed in carcinoid tumor cells.NCI
DesignNote
  • Wed Sep 12 13:52:21 EDT 2012 - See 'TPH_Inhibitor_LX1032'
code
  • C88331
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