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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Thiabendazole
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Thiabendazole
NSC_Code
  • 90507
UMLS_CUI
  • C0039832
CAS_Registry
  • 148-79-8
FDA_UNII_Code
  • N1Q45E87DT
Contributing_Source
  • FDA
ALT_DEFINITION
  • 2-Substituted benzimidazole first introduced in 1962. It is active against a variety of nematodes and is the drug of choice for strongyloidiasis. It has CNS side effects and hepatotoxic potential. (From Smith and Reynard, Textbook of Pharmacology, 1992, p919)MSH2002_06_01
PDQ_Open_Trial_Search_ID
  • 39713
PDQ_Closed_Trial_Search_ID
  • 39713
Chemical_Formula
  • C10H7N3S
Legacy_Concept_Name
  • Thiabendazole
CHEBI_ID
  • CHEBI:45979
FULL_SYN
  • THIABENDAZOLEPTFDAN1Q45E87DT
  • MK 360SYDTPNSC0090507
  • MK-360SYDTPNSC0090507
  • ThiabendazolePTNCI
  • TBZABNCI
  • MK-360CNNCI
  • MintezolSYDTPNSC0090507
  • MintezolBRNCI
  • ThibenzoleSYDTPNSC0090507
  • ThibenzoleBRNCI
DEFINITION
  • A benzimidazole derivative with anthelminthic property. Although the mechanism of action has not been fully elucidated, thiabendazole inhibits the helminth-specific mitochondrial enzyme fumarate reductase, thereby inhibiting the citric acid cycle, mitochondrial respiration and subsequent production of ATP, ultimately leading to helminth's death. In addition, it has been suggested that thiabendazole may lead to inhibition of microtubule polymerization by binding to beta-tubulin and has an overt ovicidal effect with regard to some trichostrongylids.NCI
code
  • C873
sameAs
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