About: Tetradecanoylphorbol Acetate

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Tetradecanoylphorbol Acetate
rdfs:subClassOf	Differentiation Inducer
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical
Preferred_Name	Tetradecanoylphorbol Acetate
NSC_Code	262244
UMLS_CUI	C0039654
CAS_Registry	16561-29-8
In_Clinical_Trial_For	Hematologic cancer; bone marrow disorder
FDA_UNII_Code	NI40JAQ945
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of leukemias and lymphomas. It is also being studied in the treatment of other types of cancer. Tetradecanoylphorbol acetate affects many cell actions and may cause tumor cells to die. It is a type of phorbol ester.NCI-GLOSS
PDQ_Open_Trial_Search_ID	43661
PDQ_Closed_Trial_Search_ID	43661
Chemical_Formula	C36H56O8
Legacy_Concept_Name	Tetradecanoylphorbol_Acetate
CHEBI_ID	CHEBI:37537
FULL_SYN	PMAABNCI TPAPTNCI-GLOSSCDR0000044864 Phorbol Myristate AcetateSYNCI 12-O-tetradecanoylphorbol-13-acetateSNNCI PHORBOL 12-MYRISTATE 13-ACETATE DIESTERPTFDANI40JAQ945 Tetradecanoylphorbol AcetatePTNCI TPA (Phorbol Ester)SYNCI tetradecanoylphorbol acetatePTNCI-GLOSSCDR0000663334 12-O-tetradecanoylphorbol-13-acetatePTNCI-GLOSSCDR0000046763 LonomycinSYNCI
DEFINITION	A phorbol ester with potential antineoplastic effects. Tetradecanoylphorbol acetate (TPA) induces maturation and differentiation of hematopoietic cell lines, including leukemic cells. This agent may induce gene expression and protein kinase C (PKC) activity. In addition to potential antineoplastic effects, TPA may exhibit tumor promoting activity. (NCI04)NCI
code	C866
sameAs	Tetradecanoylphorbol Acetate
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0021224
is sameAs of	Tetradecanoylphorbol Acetate Tetradecanoylphorbol Acetate

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