About: Procarbazine Hydrochloride

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Attributes	Values
rdf:type	Class
rdfs:label	Procarbazine Hydrochloride
rdfs:subClassOf	Triazenes
Has_Free_Acid_Or_Base_Form	PROCARBAZINE
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Procarbazine Hydrochloride
NSC_Code	77213
UMLS_CUI	C0205909
CAS_Registry	366-70-1
Accepted_Therapeutic_Use_For	Brain tumors; Hodgkins diseases; Non-Hodgkins lymphoma
FDA_UNII_Code	XH0NPH5ZX8
Contributing_Source	FDA
ALT_DEFINITION	A drug that is used to treat advanced Hodgkin lymphoma and is being studied in the treatment of other types of cancer. Matulane blocks cells from making proteins and damages DNA. It may kill cancer cells. It is a type of antineoplastic agent and a type of alkylating agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID	41607
PDQ_Closed_Trial_Search_ID	41607
Chemical_Formula	C12H19N3O.HCl
Legacy_Concept_Name	Procarbazine
FULL_SYN	p-toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI)SNNCI N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide HydrochlorideSNNCI N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine HydrochlorideSNNCI p-Toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI)SYDTPNSC0077213 N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide HydrochlorideSNNCI p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochlorideSNNCI PCBABNCI PCZABNCI Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI)SYDTPNSC0077213 Procarbazine HydrochloridePTNCI Ibenzmethyzine hydrochlorideSYDTPNSC0077213 procarbazine hydrochloridePTNCI-GLOSSCDR0000635746 NatulanSYDTPNSC0077213 PCB HydrochlorideSYNCI MIH hydrochlorideSYNCI MatulaneSYDTPNSC0077213 NCI-C01810SYDTPNSC0077213 NatulanFBNCI NatunalarSYDTPNSC0077213 PCB hydrochlorideSYDTPNSC0077213 MIH hydrochlorideSYDTPNSC0077213 PROCARBAZINE HYDROCHLORIDEPTFDAXH0NPH5ZX8 MatulanePTNCI-GLOSSCDR0000635747 Ro 4 6467/1SYDTPNSC0077213 MatulaneBRNCI benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI)SNNCI NatulanarFBNCI NatunalarFBNCI NCI-C01810CNNCI p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochlorideSYDTPNSC0077213 Ro 4-6467/1CNNCI
DEFINITION	The hydrochloride salt of a methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction.NCI
code	C773
sameAs	PROCARBAZINE HYDROCHLORIDE PROCARBAZINE HYDROCHLORIDE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0331268
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