About: Oncolytic Ad5-Delta 24RGD     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Oncolytic Ad5-Delta 24RGD
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Oncolytic Ad5-Delta 24RGD
NCI_META_CUI
  • CL383850
PDQ_Open_Trial_Search_ID
  • 590711
PDQ_Closed_Trial_Search_ID
  • 590711
Legacy_Concept_Name
  • Oncolytic_Ad5-Delta_24RGD
FULL_SYN
  • Oncolytic Ad5-Delta 24RGDPTNCI
  • Ad5-Delta24RGDABNCI
  • Oncolytic Adenovirus Ad5-Delta 24RGDSYNCI
DEFINITION
  • An adenovirus serotype 5 strain, selectively replication competent in cells defective in the Rb/p16 tumor suppressor pathway, with potential oncolytic activity. Oncolytic adenovirus Ad5-Delta 24RGD contains an integrin binding RGD-4C motif, allowing Coxsackie adenovirus receptor-independent infection of tumor cells, which are often deficient for Coxsackie and adenovirus receptors (CARs). Selectively replication competent in cells that are defective in retinoblastoma gene (Rb) or cyclin-dependent kinase inhibitor-2A (p16), active replication of oncolytic adenovirus Ad5-Delta 24RGD in tumor cells may induce oncolysis or cell lysis. As integral components of the late G1 restriction point, the Rb gene product and p16 are negative regulators of the cell cycle; ovarian cancer cells and non-small cell lung cancer cells may be defective in the Rb/p16 pathway.NCI
code
  • C74067
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