About: Pioglitazone     Goto   Sponge   Distinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Pioglitazone
rdfs:subClassOf
Has_Salt_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Pioglitazone
UMLS_CUI
  • C0071097
CAS_Registry
  • 111025-46-8
FDA_UNII_Code
  • X4OV71U42S
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that is used to treat type 2 diabetes and is being studied in the prevention of head and neck cancer. It may be able to stop leukoplakia (a condition affecting the mouth ) from developing into cancer. It is a type of thiazolidinedione.NCI-GLOSS
Chemical_Formula
  • C19H20N2O3S
Legacy_Concept_Name
  • Pioglitazone_Base
CHEBI_ID
  • CHEBI:8228
FULL_SYN
  • PIOGLITAZONEPTFDAX4OV71U42S
  • PioglitazonePTNCI
  • pioglitazonePTNCI-GLOSSCDR0000410212
DEFINITION
  • An orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation.NCI
code
  • C71633
sameAs
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