About: Tamibarotene     Goto   Sponge   Distinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Tamibarotene
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Tamibarotene
NSC_Code
  • 608000
UMLS_CUI
  • C0051533
CAS_Registry
  • 94497-51-5
In_Clinical_Trial_For
  • Acute Promyelocytic Leukemia
FDA_UNII_Code
  • 08V52GZ3H9
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 571791
PDQ_Closed_Trial_Search_ID
  • 571791
Chemical_Formula
  • C22H25NO3
Legacy_Concept_Name
  • Tamibarotene
CHEBI_ID
  • CHEBI:32181
FULL_SYN
  • TAMIBAROTENEPTFDA08V52GZ3H9
  • TamibarotenePTNCI
  • Am-80CNNCI
  • Retinobenzoic AcidSYNCI
DEFINITION
  • An orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. As a specific retinoic acid receptor (RAR) alpha/beta agonist, tamibarotene is approximately ten times more potent than ATRA in inducing cell differentiation and apoptosis in HL-60 (human promyelocytic leukemia) cell lines in vitro. Due to a lower affinity for cellular retinoic acid binding protein (CRABP), tamibarotene may show sustained plasma levels compared to ATRA. In addition, this agent may exhibit a lower toxicity profile than ATRA, in part, due to the lack of affinity for the RAR-gamma receptor, the major retinoic acid receptor in the dermal epithelium.NCI
code
  • C71025
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